逆行整块切除术治疗非肌肉浸润性膀胱癌可以降低肿瘤细胞播散到外周循环的风险。
Retrograde en bloc resection for non-muscle invasive bladder tumor can reduce the risk of seeding cancer cells into the peripheral circulation.
机构信息
Department of Urology, The First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, Siming District, Xiamen, 361003, Fujian, China.
MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Key Laboratory of Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Chemical and Biochemical Engineering, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361003, Fujian, China.
出版信息
World J Surg Oncol. 2020 Feb 10;18(1):33. doi: 10.1186/s12957-020-1808-0.
OBJECTIVE
To ascertain whether en bloc resection could reduce the risk of seeding cancer cells into the circulation during the resection of non-muscle invasive bladder cancer (NMIBC).
METHODS
Patients with primary NMIBC were enrolled in this prospective study from October 2017 to May 2018. Patients were allocated to receive conventional transurethral resection of the bladder (TURB) or retrograde en bloc resection technique of the bladder tumor (RERBT). Blood samples (1 ml) for circulating tumor cell (CTC) enumeration were drawn from the peripheral vein prior to resection (PV1), immediately after resection of the tumor base (PV2), and at 12 h after resection (PV3). Intra-group comparisons of the changes in the number of CTCs identified among the PV1, PV2, and PV3 blood samples were performed in each group.
RESULTS
A total of 21 patients (12 in the RERBT group and 9 in the TURB group) were recruited. For patients receiving TURB, the level of CTCs identified in PV3 was significantly higher than that in PV1 (p = 0.047). However, there was no significant difference in CTC counts before and after resection in the RERBT group.
CONCLUSION
RERBT did not increase the number of tumor cells in the bloodstream.
目的
确定整块切除术是否能降低非肌肉浸润性膀胱癌（NMIBC）切除过程中癌细胞播散到循环系统的风险。
方法
本前瞻性研究于 2017 年 10 月至 2018 年 5 月纳入了原发性 NMIBC 患者。患者被分配接受常规经尿道膀胱肿瘤切除术（TURB）或逆行整块膀胱肿瘤切除术（RERBT）。在切除前（PV1）、肿瘤基底切除后即刻（PV2）和切除后 12 小时（PV3），从外周静脉抽取 1ml 血液样本用于循环肿瘤细胞（CTC）计数。在每组内比较了各组 PV1、PV2 和 PV3 血液样本中 CTC 数量的变化。
结果
共纳入 21 例患者（RERBT 组 12 例，TURB 组 9 例）。对于接受 TURB 的患者，PV3 中 CTC 水平明显高于 PV1（p=0.047）。然而，RERBT 组在切除前后 CTC 计数无显著差异。
结论
RERBT 并未增加血液中的肿瘤细胞数量。
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