Rheumatology Unit, University of Pisa, Italy.
Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation of Pavia, Italy.
Clin Exp Rheumatol. 2020 Jan-Feb;38(1):1-10. Epub 2020 Feb 3.
The idiopathic inflammatory myopathies (IIMs) are a rare group of immune, systemic diseases characterised by muscle inflammation and frequently by extramuscular involvement. IIMs are heterogeneous with generally a chronic or subacute onset, which vary from less severe to more serious manifestations, not always easy to diagnose and even less to manage. In the past year, many studies have been published in order to clarify disease pathogenesis and improve patient management and treatment.The purpose of this review article is to provide an overview of the new insights in pathogenesis, serological findings, clinical manifestations and treatment of IIMs, summarising the most relevant studies published over the last year.
特发性炎性肌病(IIM)是一组罕见的免疫性、系统性疾病,其特征为肌肉炎症,常伴有肌肉外器官受累。IIM 具有异质性,一般呈慢性或亚急性起病,临床表现从轻到重不等,诊断不易,治疗更难。在过去的一年中,已经发表了许多研究以阐明疾病发病机制,改善患者管理和治疗。本文综述了过去一年发表的最相关研究,旨在概述 IIM 的发病机制、血清学发现、临床表现和治疗的新认识。