Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Móricz Zsigmond út 22, Debrecen, H-4032, Hungary.
Gyula Petrányi Doctoral School of Clinical Immunology and Allergology, University of Debrecen, Debrecen, Hungary.
Curr Rheumatol Rep. 2021 Jul 1;23(7):55. doi: 10.1007/s11926-021-01016-8.
This article provides an update on the most recent advances in epidemiology, pathogenesis, diagnostic procedures, and therapeutic approaches for myositis-associated bone diseases, such as osteoporosis and bone fractures.
In the recent years, several studies showed that osteoporosis and consequent fractures are a common and frequently underestimated complication in patients with idiopathic inflammatory myopathies (IIM). In younger patients, asymptomatic fractures might present in the early phase of the disease which could increase the risk of development of further fractures. High-risk patients could be selected with early application of combined diagnostic procedures, such as fracture risk scores with steroid dose adjustments and imaging. Recent advances might help clinicians from different fields of medicine in the early recognition and management of myositis-associated osteoporosis, which will potentially improve the quality of life of patients with IIM.
本文就肌炎相关骨病（如骨质疏松症和骨折）的流行病学、发病机制、诊断程序和治疗方法方面的最新进展进行了综述。
近年来，多项研究表明，骨质疏松症和由此导致的骨折是特发性炎性肌病（IIM）患者常见且常被低估的并发症。在年轻患者中，无症状骨折可能在疾病的早期出现，这可能会增加进一步骨折的风险。通过早期应用联合诊断程序（如骨折风险评分结合激素剂量调整和影像学检查），可以选择高危患者。最近的进展可能有助于医学领域的临床医生早期识别和管理肌炎相关骨质疏松症，从而提高 IIM 患者的生活质量。
