Bonomo Adriana C, Pinto-Mariz Fernanda, Riederer Ingo, Benjamim Claudia F, Butler-Browne Gillian, Mouly Vincent, Savino Wilson
Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
National Institute of Science and Technology on Neuroimmunomodulation (INCT-NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Front Physiol. 2020 Sep 18;11:573347. doi: 10.3389/fphys.2020.573347. eCollection 2020.
Growing evidence demonstrates a continuous interaction between the immune system and the skeletal muscle in inflammatory diseases of different pathogenetic origins, in dystrophic conditions such as Duchenne Muscular Dystrophy as well as during normal muscle regeneration. Although one component of the innate immunity, the macrophage, has been extensively studied both in disease conditions and during cell or gene therapy strategies aiming at restoring muscular functions, much less is known about dendritic cells and their primary immunological targets, the T lymphocytes. This review will focus on the dendritic cells and T lymphocytes (including effector and regulatory T-cells), emphasizing the potential cross talk between these cell types and their influence on the structure and function of skeletal muscle.
越来越多的证据表明，在不同致病源的炎症性疾病、诸如杜兴氏肌肉营养不良症等营养不良状况以及正常肌肉再生过程中，免疫系统与骨骼肌之间存在持续的相互作用。尽管先天性免疫的一个组成部分巨噬细胞，在疾病状况以及旨在恢复肌肉功能的细胞或基因治疗策略中都得到了广泛研究，但对于树突状细胞及其主要免疫靶点T淋巴细胞的了解却少得多。本综述将聚焦于树突状细胞和T淋巴细胞（包括效应T细胞和调节性T细胞），强调这些细胞类型之间潜在的相互作用及其对骨骼肌结构和功能的影响。
