通过蛋白质结构分析鉴别神经退行性疾病。 - Suppr

Neurodegenerative diseases distinguished through protein-structure analysis.

作者信息

Gerez Juan Atilio, Riek Roland

出版信息

Nature. 2020 Feb;578(7794):223-224. doi: 10.1038/d41586-020-00131-3.

DOI:10.1038/d41586-020-00131-3

PMID:32042086

Abstract

摘要

相似文献

Neurodegenerative diseases distinguished through protein-structure analysis.

Nature. 2020 Feb;578(7794):223-224. doi: 10.1038/d41586-020-00131-3.

α-Synuclein strains in multiple system atrophy: A product of their environment?

Mov Disord. 2018 Aug;33(8):1270. doi: 10.1002/mds.90.

Altered α-synuclein, parkin, and synphilin isoform levels in multiple system atrophy brains.

J Neurochem. 2016 Jan;136(1):172-85. doi: 10.1111/jnc.13392. Epub 2015 Nov 11.

α-Synucleinopathy phenotypes.

Parkinsonism Relat Disord. 2014 Jan;20 Suppl 1:S62-7. doi: 10.1016/S1353-8020(13)70017-8.

Conjugal multiple system atrophy: Be wary of implicating transmissibility.

Parkinsonism Relat Disord. 2020 Jun;75:121. doi: 10.1016/j.parkreldis.2020.03.004. Epub 2020 Mar 13.

The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.

Ann N Y Acad Sci. 2000;920:16-27. doi: 10.1111/j.1749-6632.2000.tb06900.x.

The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy.

J Neural Transm (Vienna). 2006 Oct;113(10):1435-9. doi: 10.1007/s00702-005-0427-9. Epub 2006 Feb 9.

Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies.

Neurosci Lett. 1998 Jul 31;251(3):205-8. doi: 10.1016/s0304-3940(98)00504-7.

Neurodegeneration: Aggregates feel the strain.

Nature. 2015 Jun 18;522(7556):296-7. doi: 10.1038/nature14526. Epub 2015 Jun 10.

Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation.

Brain. 2010 Jan;133(Pt 1):172-88. doi: 10.1093/brain/awp282. Epub 2009 Nov 10.

引用本文的文献

Targeting mitochondria with natural polyphenols for treating Neurodegenerative Diseases: a comprehensive scoping review from oxidative stress perspective.

J Transl Med. 2025 May 23;23(1):572. doi: 10.1186/s12967-025-06605-0.

On the pH-dependence of α-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation.

Elife. 2024 Aug 28;12:RP93562. doi: 10.7554/eLife.93562.

Intraoperative Hypothermia Induces Vascular Dysfunction in the CA1 Region of Rat Hippocampus.

Brain Sci. 2022 May 27;12(6):692. doi: 10.3390/brainsci12060692.

Guts Imbalance Imbalances the Brain: A Review of Gut Microbiota Association With Neurological and Psychiatric Disorders.

Front Med (Lausanne). 2022 Mar 31;9:813204. doi: 10.3389/fmed.2022.813204. eCollection 2022.

Structural and Functional Insights into α-Synuclein Fibril Polymorphism.

Biomolecules. 2021 Sep 28;11(10):1419. doi: 10.3390/biom11101419.

High-Speed Atomic Force Microscopy Reveals the Structural Dynamics of the Amyloid-β and Amylin Aggregation Pathways.

Int J Mol Sci. 2020 Jun 16;21(12):4287. doi: 10.3390/ijms21124287.

Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines.

Int J Mol Sci. 2020 Mar 31;21(7):2431. doi: 10.3390/ijms21072431.

本文引用的文献

Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy.

Nature. 2020 Feb;578(7794):273-277. doi: 10.1038/s41586-020-1984-7. Epub 2020 Feb 5.

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy.

Elife. 2019 Dec 9;8:e48907. doi: 10.7554/eLife.48907.

Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts.

Nat Commun. 2019 Dec 4;10(1):5535. doi: 10.1038/s41467-019-13564-w.

α-Synuclein strains target distinct brain regions and cell types.

Nat Neurosci. 2020 Jan;23(1):21-31. doi: 10.1038/s41593-019-0541-x. Epub 2019 Dec 2.

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases.

Elife. 2019 Feb 5;8:e43584. doi: 10.7554/eLife.43584.

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies.

Nature. 2018 May;557(7706):558-563. doi: 10.1038/s41586-018-0104-4. Epub 2018 May 9.

Mammalian prions and their wider relevance in neurodegenerative diseases.

Nature. 2016 Nov 10;539(7628):217-226. doi: 10.1038/nature20415.

Structural and functional characterization of two alpha-synuclein strains.

Nat Commun. 2013;4:2575. doi: 10.1038/ncomms3575.

Molecular structure of β-amyloid fibrils in Alzheimer's disease brain tissue.

Cell. 2013 Sep 12;154(6):1257-68. doi: 10.1016/j.cell.2013.08.035.

Mutation and selection of prions.

PLoS Pathog. 2012;8(3):e1002582. doi: 10.1371/journal.ppat.1002582. Epub 2012 Mar 29.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Neurodegenerative diseases distinguished through protein-structure analysis.

作者信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献