帕金森病和多系统萎缩患者的血浆α-突触核蛋白水平。
The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy.
作者信息
Lee P H, Lee G, Park H J, Bang O Y, Joo I S, Huh K
机构信息
Department of Neurology, Ajou University School of Medicine, Suwon, South Korea.
出版信息
J Neural Transm (Vienna). 2006 Oct;113(10):1435-9. doi: 10.1007/s00702-005-0427-9. Epub 2006 Feb 9.
alpha-Synuclein, a synaptic protein of unknown function, is a major component of Lewy bodies and may play a role in the pathophysiological process of Parkinson's disease (PD). In this study, we measured the plasma alpha-synuclein levels in 105 patients with PD, 38 patients with multiple system atrophy (MSA), and 51 age-matched controls. The alpha-synuclein level was significantly elevated in patients with PD (79.9 +/- 4.0 pg/ml, p < 0.001) and in those with MSA (78.1 +/- 3.5 pg/ml, p = 0.019) compared with the level in controls (76.1 +/- 3.9 pg/ml). The alpha-synuclein level was higher in patients with PD than in those with MSA (79.9 +/- 4.0 vs 78.1 +/- 3.5, p = 0.016). Our study demonstrated that the alpha-synuclein level in plasma is elevated in patients with PD and MSA.
α-突触核蛋白是一种功能未知的突触蛋白，是路易小体的主要成分，可能在帕金森病（PD）的病理生理过程中起作用。在本研究中，我们测量了105例帕金森病患者、38例多系统萎缩（MSA）患者和51例年龄匹配的对照者的血浆α-突触核蛋白水平。与对照组（76.1±3.9 pg/ml）相比，帕金森病患者（79.9±4.0 pg/ml，p<0.001）和多系统萎缩患者（78.1±3.5 pg/ml，p = 0.019）的α-突触核蛋白水平显著升高。帕金森病患者的α-突触核蛋白水平高于多系统萎缩患者（79.9±4.0 vs 78.1±3.5，p = 0.016）。我们的研究表明，帕金森病和多系统萎缩患者血浆中的α-突触核蛋白水平升高。
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