Guan Yueyue, Li Lei, Yang Rui, Lu Yun, Tang Jun
Department of Encephalopathy, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China.
Department of Anorectal Surgery, Hospital of Chengdu University of Traditional Chinese Medicine and Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, China.
J Transl Med. 2025 May 23;23(1):572. doi: 10.1186/s12967-025-06605-0.
Neurodegenerative diseases are a class of conditions with widespread detrimental impacts, currently lacking effective therapeutic drugs. Recent studies have identified mitochondrial dysfunction and the resultant oxidative stress as crucial contributors to the pathogenesis of neurodegenerative diseases. Polyphenols, naturally occurring compounds with inherent antioxidant properties, have demonstrated the potential to target mitochondria and mitigate oxidative stress. This therapeutic potential has garnered significant attention in recent years. Investigating the mitochondrial targeting capacity of polyphenols, their role in functional regulation, and their ability to modulate oxidative stress, along with exploring novel technologies and strategies for modifying polyphenol compounds and their formulations, holds promise for providing new avenues for the treatment of neurodegenerative diseases.
神经退行性疾病是一类具有广泛有害影响的病症，目前缺乏有效的治疗药物。最近的研究已确定线粒体功能障碍及由此产生的氧化应激是神经退行性疾病发病机制的关键因素。多酚是具有固有抗氧化特性的天然存在的化合物，已显示出靶向线粒体和减轻氧化应激的潜力。这种治疗潜力近年来已引起广泛关注。研究多酚的线粒体靶向能力、它们在功能调节中的作用及其调节氧化应激的能力，以及探索修饰多酚化合物及其制剂的新技术和策略，有望为神经退行性疾病的治疗提供新途径。
