Kolanu Bhagavan Reddy, Vadakedath Sabitha, Boddula Venugopal, Kandi Venkataramana
Biochemistry, Prathima Institute of Medical Sciences, Karimnagar, IND.
Clinical Microbiology, Prathima Institute of Medical Sciences, Karimnagar, IND.
Cureus. 2020 Jan 3;12(1):e6554. doi: 10.7759/cureus.6554.
Females go through a complex hormonal variation once they reach menarche. The menstrual cycle repeats every month regularly and is dependent on the normal functioning of the hypothalamus, pituitary, and ovarian hormones. The overall wellness of the females during the menstrual cycle depends greatly on nutritional status. It is common that women develop menstrual cycle-related symptoms and are routinely prone to thyroid dysfunction. The present study is carried out to assess the activities of Mg and thyroid hormones in pre-, peri-, and post-menopausal women.
A total of 165 women were recruited in the study after satisfying the inclusion criteria. An equal number of age-matched subjects were included as controls. All the subjects included in the study were selected from the patients attending various out-patient departments of the Prathima Institute of Medical Sciences, Karimnagar, Telangana, India. Blood samples from each subject were collected and analyzed by a semi-automated analyzer for the activities of Mg, and thyroid hormones tetra-iodothyronine (T), tri-iodothyronine (T), and thyroid-stimulating hormone (TSH).
There was a statistically significant relationship between the serum Mg activities and the thyroid hormones between the study subjects and the control group. The activities of the serum Mg (1.72±0.33) in relation to the TSH (5.09±7.54) in the cases were found statistically significant (p <0.001) when compared to the serum Mg (1.8±0.20) in relation to the TSH in the control group (2.41±2.05). The activities of Mg were noted to fall in women through the peri (1.70±0.43), and postmenopausal age (1.60±0.34). There was a significant increase in the activities of TSH in women of premenopause (4.27±5.76), perimenopause (5.65±8.53), and postmenopausal age (7.19±11.07). Conclusion: From the results of the present study, it can be concluded that the women reaching menopause could suffer from hypomagnesemia and inturn may develop thyroid and other hormonal disorders.
女性初潮后会经历复杂的激素变化。月经周期每月有规律地重复，且依赖于下丘脑、垂体和卵巢激素的正常功能。女性在月经周期中的整体健康状况很大程度上取决于营养状况。女性出现与月经周期相关的症状并经常容易出现甲状腺功能障碍是很常见的。本研究旨在评估绝经前、围绝经期和绝经后女性体内镁和甲状腺激素的活性。
在满足纳入标准后，共招募了165名女性参与研究。纳入了同等数量年龄匹配的受试者作为对照。研究中纳入的所有受试者均选自印度特伦甘纳邦卡里姆纳加尔普拉蒂玛医学科学研究所各门诊部门的患者。采集每个受试者的血样，并用半自动分析仪分析镁、甲状腺激素四碘甲状腺原氨酸（T4）、三碘甲状腺原氨酸（T3）和促甲状腺激素（TSH）的活性。
研究对象与对照组之间血清镁活性与甲状腺激素之间存在统计学显著关系。与对照组血清镁（1.8±0.20）相对于促甲状腺激素（2.41±2.05）相比，病例组血清镁（1.72±0.33）相对于促甲状腺激素（5.09±7.54）具有统计学显著性（p<0.001）。镁活性在围绝经期（1.70±0.43）和绝经后年龄（1.60±0.34）的女性中有所下降。绝经前（4.27±5.76）、围绝经期（5.65±8.53）和绝经后年龄（7.19±11.07）女性的促甲状腺激素活性显著增加。结论：从本研究结果可以得出结论，进入更年期的女性可能患有低镁血症，进而可能出现甲状腺和其他激素紊乱。
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