Schwalfenberg Gerry K, Genuis Stephen J
Department of Family Medicine, University of Alberta, No. 301, 9509-156 Street, Edmonton, AB, Canada T5P 4J5.
Faculty of Medicine, University of Alberta, 2935-66 Street, Edmonton, AB, Canada T6K 4C1.
Scientifica (Cairo). 2017;2017:4179326. doi: 10.1155/2017/4179326. Epub 2017 Sep 28.
The scientific literature provides extensive evidence of widespread magnesium deficiency and the potential need for magnesium repletion in diverse medical conditions. Magnesium is an essential element required as a cofactor for over 300 enzymatic reactions and is thus necessary for the biochemical functioning of numerous metabolic pathways. Inadequate magnesium status may impair biochemical processes dependent on sufficiency of this element. Emerging evidence confirms that nearly two-thirds of the population in the western world is not achieving the recommended daily allowance for magnesium, a deficiency problem contributing to various health conditions. This review assesses available medical and scientific literature on health issues related to magnesium. A traditional integrated review format was utilized for this study. Level I evidence supports the use of magnesium in the prevention and treatment of many common health conditions including migraine headache, metabolic syndrome, diabetes, hyperlipidemia, asthma, premenstrual syndrome, preeclampsia, and various cardiac arrhythmias. Magnesium may also be considered for prevention of renal calculi and cataract formation, as an adjunct or treatment for depression, and as a therapeutic intervention for many other health-related disorders. In clinical practice, optimizing magnesium status through diet and supplementation appears to be a safe, useful, and well-documented therapy for several medical conditions.
科学文献提供了大量证据，证明普遍存在镁缺乏现象，以及在各种医疗状况下可能需要补充镁。镁是一种必需元素，作为300多种酶促反应的辅助因子，因此对众多代谢途径的生化功能至关重要。镁状态不足可能会损害依赖该元素充足供应的生化过程。新出现的证据证实，西方世界近三分之二的人口未达到镁的推荐每日摄入量，这一缺乏问题导致了各种健康状况。本综述评估了关于与镁相关的健康问题的现有医学和科学文献。本研究采用传统的综合综述形式。一级证据支持镁用于预防和治疗许多常见健康状况，包括偏头痛、代谢综合征、糖尿病、高脂血症、哮喘、经前综合征、先兆子痫和各种心律失常。镁还可考虑用于预防肾结石和白内障形成，作为抑郁症的辅助治疗或治疗方法，以及作为许多其他与健康相关疾病的治疗干预措施。在临床实践中，通过饮食和补充剂优化镁状态似乎是一种安全、有用且有充分文献记载的治疗多种医疗状况的方法。
