Department of Animal Life and Environment Science, Hankyong National University, 327 Jungang-ro, Anseong-si, 17579, Republic of Korea.
Department of Animal Science and Technology, Chung-Ang University, 4726 Seodong-daero, Daedeok-myeon, Anseong-si, Gyeonggi, 17546, Republic of Korea.
Environ Sci Pollut Res Int. 2020 Apr;27(12):14207-14215. doi: 10.1007/s11356-020-07994-z. Epub 2020 Feb 10.
This study was performed to determine the effects of in vitro human digestion on the concentrations of five insecticides, namely 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD), 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (DDE), bifenthrin, and fipronil. In vitro models included all the steps of human digestion, i.e., passage through the mouth, stomach, small intestine, and large intestine (with enteric bacteria). The concentrations of DDT and fipronil did not change (P > 0.05) until small intestinal digestion, whereas those of DDD, DDE, and bifenthrin decreased (P < 0.05) at each digestion step. The concentrations of all the insecticides decreased (P < 0.05) during the large intestinal digestion step with enteric bacteria, Lactobacillus sakei and Escherichia coli. In conclusion, the concentrations of all the tested insecticides decreased during all the steps of in vitro human digestion and were especially reduced by enteric bacteria during the large intestinal digestion step.
本研究旨在确定体外人体消化对五种杀虫剂浓度的影响，这五种杀虫剂分别为 1,1,1-三氯-2,2-双（对氯苯基）乙烷（DDT）、1,1-二氯-2,2-双（对氯苯基）乙烷（DDD）、2,2-双（对氯苯基）-1,1-二氯乙烯（DDE）、联苯菊酯和氟虫腈。体外模型包括人体消化的所有步骤，即经过口腔、胃、小肠和大肠（有肠内细菌）。直到小肠消化，DDT 和氟虫腈的浓度没有变化（P＞0.05），而 DDD、DDE 和联苯菊酯的浓度在每个消化步骤中都降低（P＜0.05）。在含有肠内细菌、清酒乳杆菌和大肠杆菌的大肠消化步骤中，所有杀虫剂的浓度都降低了（P＜0.05）。总之，在体外人体消化的所有步骤中，所有测试的杀虫剂浓度都降低了，特别是在大肠消化步骤中，肠内细菌使它们的浓度降低了。
