Biosynthesis of staurosporine, 1. 1H- and 13C-NMR assignments.
作者信息
Meksuriyen D, Cordell G A
机构信息
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60612.
出版信息
J Nat Prod. 1988 Sep-Oct;51(5):884-92. doi: 10.1021/np50059a012.
PMID:3204380
Abstract
Complete and unambiguous assignments of the 1H- and 13C-nmr spectra of the potent antitumor antibiotic staurosporine have been accomplished using a combination of one- and two-dimensional nmr techniques, including one-bond and long-range heteronuclear multiple-quantum coherence spectroscopy (HMQC). Staurosporine was found to be highly cytotoxic in the KB and P-388 assays but was inactive in the microtubulin assembly assay.
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