Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK.
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK.
Exp Cell Res. 2020 Apr 15;389(2):111899. doi: 10.1016/j.yexcr.2020.111899. Epub 2020 Feb 8.
Centromeres are highly specialized genomic loci that function during mitosis to maintain genome stability. Formed primarily on repetitive α-satellite DNA sequence characterisation of native centromeric chromatin structure has remained challenging. Fortuitously, neocentromeres are formed on a unique DNA sequence and represent an excellent model to interrogate centromeric chromatin structure. This review uncovers the specific findings from independent neocentromere studies that have advanced our understanding of canonical centromere chromatin structure.
着丝粒是高度特化的基因组位点，在有丝分裂过程中起作用，以维持基因组的稳定性。虽然主要由重复的α-卫星 DNA 序列组成，但对天然着丝粒染色质结构的特征描述一直具有挑战性。幸运的是，新着丝粒是在独特的 DNA 序列上形成的，是研究着丝粒染色质结构的极佳模型。这篇综述揭示了独立的新着丝粒研究的具体发现，这些发现增进了我们对典型着丝粒染色质结构的理解。
