血清 Metrnl 水平与 2 型糖尿病患者内脏脂肪肥胖（VFO）呈负相关。

Inverse relationship between serum Metrnl levels and visceral fat obesity (VFO) in patients with type 2 diabetes.

机构信息

Department of Endocrinology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu Province, China.

出版信息

Diabetes Res Clin Pract. 2020 Mar;161:108068. doi: 10.1016/j.diabres.2020.108068. Epub 2020 Feb 7.

DOI:10.1016/j.diabres.2020.108068

PMID:32044349

Abstract

AIM

The relationship between serum Metrnl levels and visceral fat obesity (VFO) remains unclear. This study aimed to investigate the association between serum Metrnl levels and VFO in Chinese patients with type 2 diabetes.

METHODS

A total of 321 Chinese patients with type 2 diabetes (226 men and 95 postmenopausal women aged 61.4 ± 6.5 years, BMI 25.1 ± 3.2 kg/m) were evaluated. Serum Metrnl levels were measured by enzyme linked-immunosorbent assay. Visceral fat area (VFA) was quantified via Dual Energy X-ray Absorptiometry (DXA). Correlation analyses were carried out for serum Metrnl levels and VFO.

RESULTS

VFO groups (VFA ≧100 cm) have lower serum Metrnl levels than non-VFO groups (VFA < 100 cm) (578.9 ± 225.1 vs. 684.9 ± 263.8, P = 0.001). An increasing trend in serum Metrnl levels was found to accompany the decrease in VFA. Serum Metrnl levels were negatively correlated with VFA, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and albumin (ALB), but positively correlated with age, height, blood urea nitrogen (BUN), creatinine (Cr) and uric acid (UA) (all P < 0.05). Binary logistic regression analysis showed that serum Metrnl was inversely associated with VFO even after adjusted age, gender, height, TC, TG, LDL-C, ALB, BUN, Cr, and UA (odds ration [OR], 0.846; confidence interval [CI], 0.745-0.961; P = 0.010). The optimal cut-off value of serum Metrnl levels that predicted VFO was 671.3 ng/ml (95%CI = 0.55-0.70, P = 0.001).

CONCLUSIONS

Serum Metrnl levels were inversely correlated with VFO and may be a useful indicator of VFO in Chinese patients with type 2 diabetes.

摘要

目的

血清 Metrnl 水平与内脏脂肪肥胖（VFO）之间的关系尚不清楚。本研究旨在探讨中国 2 型糖尿病患者血清 Metrnl 水平与 VFO 的关系。

方法

共评估了 321 例中国 2 型糖尿病患者（男 226 例，绝经后女 95 例，年龄 61.4±6.5 岁，BMI 25.1±3.2kg/m²）。通过酶联免疫吸附试验测定血清 Metrnl 水平。通过双能 X 射线吸收法（DXA）定量内脏脂肪面积（VFA）。对血清 Metrnl 水平与 VFO 进行相关性分析。

结果

VFO 组（VFA≧100cm）的血清 Metrnl 水平低于非 VFO 组（VFA＜100cm）（578.9±225.1 与 684.9±263.8，P=0.001）。随着 VFA 的降低，血清 Metrnl 水平呈逐渐下降趋势。血清 Metrnl 水平与 VFA、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和白蛋白（ALB）呈负相关，与年龄、身高、血尿素氮（BUN）、肌酐（Cr）和尿酸（UA）呈正相关（均 P＜0.05）。二元逻辑回归分析显示，在校正年龄、性别、身高、TC、TG、LDL-C、ALB、BUN、Cr 和 UA 后，血清 Metrnl 与 VFO 呈负相关（比值比[OR]，0.846；95%置信区间[CI]，0.745-0.961；P=0.010）。预测 VFO 的血清 Metrnl 水平的最佳截断值为 671.3ng/ml（95%CI=0.55-0.70，P=0.001）。