Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, China (mainland).
Institute of Endocrine and Metabolic Diseases of Shandong University, Jinan, Shandong, China (mainland).
Med Sci Monit. 2019 Nov 25;25:8968-8974. doi: 10.12659/MSM.920222.
BACKGROUND Metrnl is a novel identified adipomyokine which might have therapeutic potential for metabolic and inflammatory diseases, including type 2 diabetes mellitus. We aimed to explore the associations of circulating Metrnl level with ß-cell function and insulin resistance (IR) and further explore the possible correlation between Metrnl and another adipomyokine named irisin in patients diagnosed type 2 diabetes. MATERIAL AND METHODS Our study recruited 59 participants with type 2 diabetes and 30 normal glucose tolerance (NGT) participants. We used enzyme-linked immunosorbent assay (ELISA) to measure serum levels of Metrnl and irisin. The associations of Metrnl level with indexes of ß-cell function and IR and irisin level were analyzed by multiple linear regression analysis or spearman correlation analysis. RESULTS Compared with NGT participants, serum Metrnl level was elevated in participants with type 2 diabetes: 210.30 pg/mL (range 105.94-323.91 pg/mL) versus 132.02 pg/mL (range 104.93-195.92 pg/mL). Metrnl level did not show significant correlation with ß-cell function-related indicators, but positively correlated with HOMA2-IR and negatively correlated with HOMA2-%S after controlling multiple covariates in participants with type 2 diabetes. Metrnl level was also not associated with obesity-related indicators (body mass index, waist circumference, body fat percentage, and visceral adipose tissue area) in the type 2 diabetes group. In addition, the correlation between Metrnl and irisin level was also not present (r=-0.159, P=0.229) in type 2 diabetes group. CONCLUSIONS Serum Metrnl level was associated with IR, but not with ß-cell function in participants with diagnosed type 2 diabetes.
Metrnl 是一种新发现的脂肪肌因子，可能对代谢和炎症性疾病具有治疗潜力，包括 2 型糖尿病。我们旨在探讨循环 Metrnl 水平与 β细胞功能和胰岛素抵抗（IR）的相关性，并进一步探讨在诊断为 2 型糖尿病的患者中 Metrnl 与另一种脂肪肌因子叫鸢尾素之间的可能相关性。
我们的研究纳入了 59 名 2 型糖尿病患者和 30 名正常糖耐量（NGT）参与者。我们使用酶联免疫吸附测定（ELISA）法测量血清 Metrnl 和鸢尾素水平。采用多元线性回归分析或 Spearman 相关分析，分析 Metrnl 水平与 β细胞功能和 IR 及鸢尾素水平的相关性。
与 NGT 参与者相比，2 型糖尿病患者血清 Metrnl 水平升高：210.30 pg/mL（范围 105.94-323.91 pg/mL）与 132.02 pg/mL（范围 104.93-195.92 pg/mL）。Metrnl 水平与与 β细胞功能相关的指标无显著相关性，但在控制 2 型糖尿病患者的多个协变量后，与 HOMA2-IR 呈正相关，与 HOMA2-%S 呈负相关。Metrnl 水平与 2 型糖尿病组肥胖相关指标（体重指数、腰围、体脂百分比和内脏脂肪组织面积）也无相关性。此外，2 型糖尿病组中 Metrnl 与鸢尾素水平之间也不存在相关性（r=-0.159，P=0.229）。
在诊断为 2 型糖尿病的患者中，血清 Metrnl 水平与 IR 相关，而与 β细胞功能无关。
