Bansal M P, Gupta G
Department of Biophysics, Panjab University, Chandigarh, India.
J Environ Pathol Toxicol Oncol. 1988;8(7 Spec No):49-53.
Incidence of skin papillomas/tumors have been studied in ICRC male mice after surface application of 3-methylcholanthrene (MCA) after selenium treatment. Decrease in percentage incidence and tumor burden was noticed. Also increase in latent period of induction was observed. As no influence of selenium was noticed on arylhydrocarbon-hydroxylase activity in skin and liver, so activation/inactivation of carcinogen is ruled out with selenium treatment. Since there is significant increase in glutathione S-transferase activity with selenium treatment, hence detoxication pathways may be active in suppression of carcinogenic activity with selenium treatment.
在对雄性ICRC小鼠进行硒处理后，通过表面涂抹3-甲基胆蒽（MCA），对皮肤乳头状瘤/肿瘤的发生率进行了研究。发现发生率百分比和肿瘤负荷有所降低。还观察到诱导潜伏期增加。由于未发现硒对皮肤和肝脏中的芳烃羟化酶活性有影响，因此排除了硒处理对致癌物的激活/失活作用。由于硒处理后谷胱甘肽S-转移酶活性显著增加，因此解毒途径可能在硒处理抑制致癌活性中发挥作用。
