Luan Chonglin, Luan Haipei, Luo Dawei
School of Applied Chemistry and Biotechnology, Shenzhen Polytechnic, Shenzhen 518055, China.
School of Dentistry, University of Detroit Mercy , Detroit, MI 48208, USA.
Micromachines (Basel). 2020 Feb 8;11(2):176. doi: 10.3390/mi11020176.
Liquid crystal biosensors are based on changes in the orientation of liquid crystal molecules induced by specific bonding events of biomolecules. These biosensors are expected to serve as a promising system to detect biomolecules, biomolecular activity, and even small chemical molecules because they are inexpensive, sensitive, simple, effective, and portable. Herein, we introduce the principle and fabrication of liquid crystal biosensors and review the research progress in signal-amplified technology for liquid crystal sensing and its application in the detection of viruses, bacteria, proteins, nucleic acids, and small chemical molecules. In addition, the current theoretical and practical issues related to liquid crystal biosensors were investigated.
液晶生物传感器基于生物分子的特定结合事件所诱导的液晶分子取向变化。这些生物传感器有望成为一种有前景的系统，用于检测生物分子、生物分子活性，甚至小分子化学物质，因为它们价格低廉、灵敏度高、简单有效且便于携带。在此，我们介绍液晶生物传感器的原理和制造方法，并综述液晶传感信号放大技术的研究进展及其在病毒、细菌、蛋白质、核酸和小分子化学物质检测中的应用。此外，还研究了与液晶生物传感器相关的当前理论和实际问题。
