Sonobe H, Hayashi K, Takahashi K, Ohtsuki Y, Moriki T, Tsukahara Y, Sagara Y
2nd Dept. of Pathology, Kochi Medical School.
Gan No Rinsho. 1988 Nov;34(14):2019-22.
A case of lipoleiomyoma, measuring 4 x 4.5 x 5 cm, in the uterine corpus is reported in a 64-year-old multiparous woman. Histologically, the tumor was mostly composed of mature fatty tissue intermingled with small amount of fibrous and smooth muscle components in an irregularly reticular or clustered pattern. Immunohistochemically fibroblast-like cells around the perivascular areas of the fibrous components were positive in various numbers for S-100 protein, desmin, vimentin, neuron specific enolase, alpha 1-antichymotrypsin and Factor VIII. These results indicated the possibility that the present lipoleiomyoma was derived from multipotential undifferentiated mesenchymal cells, resembling fibroblast-like cells.
报道了一例64岁经产妇子宫体部的脂肪平滑肌瘤，大小为4×4.5×5cm。组织学上，肿瘤主要由成熟脂肪组织组成，混有少量纤维和平滑肌成分，呈不规则网状或簇状分布。免疫组化显示，纤维成分血管周围区域的成纤维细胞样细胞不同程度地表达S-100蛋白、结蛋白、波形蛋白、神经元特异性烯醇化酶、α1-抗糜蛋白酶和因子VIII。这些结果提示，本例脂肪平滑肌瘤可能起源于多潜能未分化间充质细胞，类似于成纤维细胞样细胞。
