一例采用舍曲林联合阿立哌唑增效治疗的创伤后应激障碍合并创伤后强迫症病例。
A Case of Comorbid PTSD and Posttraumatic OCD Treated with Sertraline-Aripiprazole Augmentation.
作者信息
Rossi Rodolfo, Niolu Cinzia, Siracusano Alberto, Rossi Alessandro, Di Lorenzo Giorgio
机构信息
Chair of Psychiatry, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Psychiatry and Clinical Psychology Unit, Fondazione Policlinico Tor Vergata, Rome, Italy.
出版信息
Case Rep Psychiatry. 2020 Jan 27;2020:2616492. doi: 10.1155/2020/2616492. eCollection 2020.
Several studies report on traumatic history in Obsessive Compulsive Disorder (OCD) and comorbidity between Posttraumatic Stress Disorder (PTSD) and OCD. First-line pharmacological treatments for both OCD and PTSD are primarily based on antidepressants, including Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin-Noradrenaline Reuptake Inhibitors (SNRI) such as Venlafaxine for PTSD. Second-Generation Antipsychotic (SGA) augmentation has shown good outcomes for nonresponsive OCD cases. However, evidence on the use of SGA in PTSD is more limited. In the present paper, we report on comorbid OCD-PTSD successfully treated with aripiprazole augmentation of sertraline. Shared psychopathological and pharmacological aspects of the disorders are discussed.
多项研究报告了强迫症（OCD）中的创伤史以及创伤后应激障碍（PTSD）与OCD之间的共病情况。OCD和PTSD的一线药物治疗主要基于抗抑郁药，包括选择性5-羟色胺再摄取抑制剂（SSRIs）和5-羟色胺-去甲肾上腺素再摄取抑制剂（SNRI），如用于治疗PTSD的文拉法辛。第二代抗精神病药物（SGA）增效治疗对难治性OCD病例显示出良好疗效。然而，关于SGA在PTSD治疗中的应用证据更为有限。在本文中，我们报告了通过阿立哌唑增效舍曲林成功治疗共病的OCD-PTSD的病例。文中还讨论了这些疾病共有的精神病理学和药理学方面的问题。
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