Fang Yujing, Xiao Binyi, Peng Jianhong, Tian Huan, Wang Fulong, Kong Lingheng, Lin Shiyong, Li Jibin, Su Qiying, Luo Kunwu, Ye Meixian, Ou Qingjian, Fan Wenhua, Li Cong, Lin Junzhong, Zhang Rongxin, Zhou Wenhao, Li Liren, Chen Gong, Lu Zhenhai, Wu Xiaojun, Ding Peirong, Zheng Meichun, Yang Xia, Pan Zhizhong, Wan Desen
Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China.
Dadong Street Community Health Service Center, Guangzhou 510000, China.
Ann Transl Med. 2019 Nov;7(21):604. doi: 10.21037/atm.2019.09.75.
We launched a screening program for colorectal cancer (CRC) in Yuexiu District, Guangzhou, China, in 2014. Here we aimed to report the early results of the program and evaluate the benefits of a screening questionnaire.
Residents aged between 50 and 74 were eligible for the screening. A questionnaire and two consecutive fecal immunological tests (FITs) were used as primary screening methods. Subjects who were positive for any of the two tests were referred for further examination with colonoscopy. Neoplasms were removed either colonoscopically or by colectomy. Atypical adenoma and CRC were defined as advanced neoplasms.
A total of 6,971 residents in Dadong Street, Yuexiu District were screened with a questionnaire, and among them, 5,343 underwent at least one FIT. Four thousand and two hundred eleven (60.4%) were female, and 2,760 (39.6%) were male, with a median age of 62.0 years. Questionnaire and FITs identified 1,219 candidates for further examination with colonoscopy, among whom only 647 (53.1%) comply. As of this writing, 623 colonoscopy results were obtained, among which 270 (43.3%) had positive findings. The adenoma detection rate (ADR) was 43.3% (270/623). The ADR was 43.3% (270/623). Of the 270 patients, 10 (3.07%) had CRC, 81 (30.0%) had advanced adenoma, 178 had low-grade adenoma or other benign polyps, one had carcinoid. Except for three advanced CRC, all neoplasms detected were benign or in an early stage.
Our screening program help identified patients with colonic neoplasms at an early stage, precluding them from developing into the malignant disease. The addition of the questionnaire significantly increased the sensitivity of primary screening, while also decreasing the specificity. Long-term results should evaluate the social and economic benefits of this program.
2014年我们在中国广州越秀区启动了一项结直肠癌（CRC）筛查项目。在此，我们旨在报告该项目的早期结果，并评估筛查问卷的益处。
年龄在50至74岁之间的居民 eligible for the screening。一份问卷和连续两次粪便免疫化学检测（FITs）被用作主要筛查方法。两项检测中任何一项呈阳性的受试者被转诊进行结肠镜进一步检查。肿瘤通过结肠镜检查或结肠切除术切除。非典型腺瘤和CRC被定义为高级别肿瘤。
越秀区大东街共有6971名居民接受了问卷调查，其中5343人至少接受了一次FIT检测。4211人（60.4%）为女性，2760人（39.6%）为男性，中位年龄为62.0岁。问卷和FITs共确定了1219名需要进一步进行结肠镜检查的候选人，其中只有647人（53.1%）依从。截至撰写本文时，获得了623份结肠镜检查结果，其中270份（43.3%）有阳性发现。腺瘤检出率（ADR）为43.3%（270/623）。在这270例患者中，10例（3.07%）患有CRC，81例（30.0%）患有高级别腺瘤，178例患有低级别腺瘤或其他良性息肉，1例患有类癌。除了3例晚期CRC外，所有检测到的肿瘤均为良性或处于早期阶段。
我们的筛查项目有助于早期识别结肠肿瘤患者，防止其发展为恶性疾病。问卷的加入显著提高了初筛的敏感性，但也降低了特异性。长期结果应评估该项目的社会和经济效益。
原文中“eligible for the screening”表述不完整，可能影响准确理解，推测完整意思可能是“符合筛查条件” 。
