Joseph Djenaba A, Meester Reinier G S, Zauber Ann G, Manninen Diane L, Winges Linda, Dong Fred B, Peaker Brandy, van Ballegooijen Marjolein
Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.
Department of Public Health, Erasmus MC, Rotterdam, the Netherlands.
Cancer. 2016 Aug 15;122(16):2479-86. doi: 10.1002/cncr.30070. Epub 2016 May 20.
In 2014, a national campaign was launched to increase colorectal cancer (CRC) screening rates in the United States to 80% by 2018; it is unknown whether there is sufficient colonoscopy capacity to reach this goal. This study estimated the number of colonoscopies needed to screen 80% of the eligible population with fecal immunochemical testing (FIT) or colonoscopy and determined whether there was sufficient colonoscopy capacity to meet the need.
The Microsimulation Screening Analysis-Colon model was used to simulate CRC screening test use in the United States (2014-2040); the implementation of a national screening program in 2014 with FIT or colonoscopy with 80% participation was assumed. The 2012 Survey of Endoscopic Capacity (SECAP) estimated the number of colonoscopies that were performed and the number that could be performed.
If a national screening program started in 2014, by 2024, approximately 47 million FIT procedures and 5.1 million colonoscopies would be needed annually to screen the eligible population with a program using FIT as the primary screening test; approximately 11 to 13 million colonoscopies would be needed annually to screen the eligible population with a colonoscopy-only screening program. According to the SECAP survey, an estimated 15 million colonoscopies were performed in 2012, and an additional 10.5 million colonoscopies could be performed.
The estimated colonoscopy capacity is sufficient to screen 80% of the eligible US population with FIT, colonoscopy, or a mix of tests. Future analyses should take into account the geographic distribution of colonoscopy capacity. Cancer 2016;122:2479-86. © 2016 American Cancer Society.
2014年,美国发起了一项全国性运动,目标是到2018年将结直肠癌(CRC)筛查率提高到80%;目前尚不清楚是否有足够的结肠镜检查能力来实现这一目标。本研究估计了通过粪便免疫化学检测(FIT)或结肠镜检查对80%符合条件的人群进行筛查所需的结肠镜检查数量,并确定是否有足够的结肠镜检查能力来满足这一需求。
使用微模拟筛查分析-结肠模型来模拟美国(2014 - 2040年)的CRC筛查测试使用情况;假设2014年实施一项全国性筛查计划,采用FIT或结肠镜检查,参与率为80%。2012年内镜检查能力调查(SECAP)估计了已进行的结肠镜检查数量以及可进行的结肠镜检查数量。
如果2014年开始实施全国性筛查计划,到2024年,若以FIT作为主要筛查测试的计划来筛查符合条件的人群,每年大约需要进行4700万次FIT检测和510万次结肠镜检查;若仅采用结肠镜检查的筛查计划来筛查符合条件的人群,每年大约需要进行1100万至1300万次结肠镜检查。根据SECAP调查,2012年估计进行了1500万次结肠镜检查,另外还可进行1050万次结肠镜检查。
估计的结肠镜检查能力足以通过FIT、结肠镜检查或多种检查组合对80%符合条件的美国人群进行筛查。未来的分析应考虑结肠镜检查能力的地理分布情况。《癌症》2016年;122:2479 - 86。©2016美国癌症协会。