Chen Xi, Jiang Yuchao, Chen Lin, He Hui, Dong Li, Hou Changyue, Duan Mingjun, Yang Mi, Yao Dezhong, Luo Cheng
Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu, China.
Key Laboratory for NeuroInformation of Ministry of Education, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of ChinaChengdu, China; Department of Psychiatry, The Fourth People's Hospital ChengduChengdu, China.
Front Neurosci. 2017 Jan 30;11:25. doi: 10.3389/fnins.2017.00025. eCollection 2017.
In the current study, FOur-dimensional Consistency of local neural Activities (FOCA) analysis was used to investigate the local consistency by integrating the temporal and spatial information of the local region. In the current study, resting-state fMRI data of 69 schizophrenia patients and 70 healthy controls were collected. FOCA was utilized to investigate the local consistency. Moreover, Granger causal analysis was used to investigate causal functional connectivity among these areas, which exhibited significantly different local consistency between groups. Compared with the healthy controls, the schizophrenia patients exhibited increased local consistency in hippocampus, basal ganglia and cerebellum regions, and decreased local consistency in sensoriperceptual cortex. In addition, altered causal functional connectivity was observed in hippocampo-cerebello-cortical (occipital) circuit. These findings suggested that this circuit might play a role in the motor dysfunction in schizophrenia, and should be paid more attention in future.
在本研究中，采用局部神经活动的四维一致性（FOCA）分析，通过整合局部区域的时间和空间信息来研究局部一致性。在本研究中，收集了69例精神分裂症患者和70例健康对照的静息态功能磁共振成像数据。利用FOCA来研究局部一致性。此外，采用格兰杰因果分析来研究这些区域之间的因果功能连接，结果显示两组之间局部一致性存在显著差异。与健康对照相比，精神分裂症患者海马体、基底神经节和小脑区域的局部一致性增加，而感觉运动皮层的局部一致性降低。此外，在海马-小脑-皮质（枕叶）回路中观察到因果功能连接的改变。这些发现表明，该回路可能在精神分裂症的运动功能障碍中起作用，未来应予以更多关注。
