Department of Pediatric Infectious Diseases, Apollo Hospitals, CBD Belapur, Navi Mumbai, India.
Indian J Pediatr. 2020 Oct;87(10):828-832. doi: 10.1007/s12098-020-03214-1. Epub 2020 Feb 11.
Influenza continues to baffle humans by its constantly changing nature. The twenty-first century has witnessed considerable advances in the understanding of the influenza viral pathogenesis, its synergy with bacterial infections and diagnostic methods. However, challenges continue: to find a less expensive and more reliable point-of-care test for use in developing countries, to produce more efficacious antiviral drugs, to explore ways to combat emerging antiviral resistance and to develop vaccines that can either be produced in a shorter production time or can overcome the need for annual matching with the circulating influenza strains. Most importantly for India, as a nation that suffered the highest mortality in the influenza pandemic 1918, there is an urgent need to gear up our existing preparedness for the next pandemic which is capable to hit at any moment in time.
流感不断变化的特性使其一直困扰着人类。在 21 世纪，人们对流感病毒发病机制、与细菌感染的协同作用以及诊断方法的理解取得了重大进展。然而，挑战依然存在：找到一种更廉价、更可靠的即时检测方法，用于发展中国家；生产更有效的抗病毒药物；探索对抗新出现的抗病毒耐药性的方法；开发能够缩短生产时间或能够克服与流行流感株每年匹配需求的疫苗。对于印度来说，最重要的是，作为在 1918 年流感大流行中死亡率最高的国家，印度迫切需要加强现有的防范措施，以应对随时可能爆发的下一次流感大流行。
