Department of Physiology, Faculty of Medicine, Yozgat Bozok University, Yozgat, 66200, Turkey.
Department of Physiology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Pharmacol Rep. 2020 Aug;72(4):984-991. doi: 10.1007/s43440-019-00049-2. Epub 2020 Jan 8.
Gastric ulcer is a very common gastrointestinal disease that may be dangerous and even may lead to death. The current study was conducted to detect the prophylactic effects of agomelatine on indomethacin-induced gastric ulcer.
In this study, a total of 5 groups were created as the sham, ulcer, omeprazole, agomelatine 1 mg/kg and agomelatine 5 mg/kg groups. The effects of agomelatine on indomethacin-induced gastric injury were investigated. Total antioxidant and oxidant levels; the oxidant parameters like oxidative stress index and the inflammation markers such as tumor necrosis factor-α, interleukin-1β, interleukin-6 and interleukin-10 levels in stomach tissue were determined by ELISA. In addition, the gastric mucosal injury occurred in stomach wall was examined with histopathological methods.
While the levels of the inflammatory markers, total oxidant status and oxidative stress index increased at an obvious level especially in the indomethacin group, the total antioxidant status levels decreased. It was observed that these parameters were improved at a significant level in agomelatine 1 mg/kg and agomelatine 5 mg/kg groups when compared to ulcer group; and the results were similar to omeprazole group. It was also observed that our histopathological findings were consistent with all our other results.
The results of this study showed that agomelatine usage in indomethacin-induced gastric ulcer model provides beneficial results.
胃溃疡是一种非常常见的胃肠道疾病，可能很危险，甚至可能导致死亡。本研究旨在检测阿戈美拉汀对吲哚美辛诱导的胃溃疡的预防作用。
在这项研究中，共创建了 5 组，即假手术组、溃疡组、奥美拉唑组、阿戈美拉汀 1mg/kg 组和阿戈美拉汀 5mg/kg 组。研究了阿戈美拉汀对吲哚美辛诱导的胃损伤的影响。通过 ELISA 测定总抗氧化和氧化水平；氧化应激指数等氧化参数和肿瘤坏死因子-α、白细胞介素-1β、白细胞介素-6 和白细胞介素-10 等炎症标志物在胃组织中的水平。此外，还通过组织病理学方法检查了胃壁中发生的胃黏膜损伤。
虽然吲哚美辛组的炎症标志物、总氧化状态和氧化应激指数水平明显升高，总抗氧化状态水平降低，但阿戈美拉汀 1mg/kg 和 5mg/kg 组的这些参数明显改善，与溃疡组相比；结果与奥美拉唑组相似。我们的组织病理学发现也与我们的其他所有结果一致。
这项研究的结果表明，阿戈美拉汀在吲哚美辛诱导的胃溃疡模型中的使用提供了有益的结果。
