Center for Traditional Chinese Medicine and Immunology Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Immunology and Pathogenic Biology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
J Cell Mol Med. 2020 Mar;24(6):3282-3291. doi: 10.1111/jcmm.15054. Epub 2020 Feb 12.
Non-small-cell lung cancer (NSCLC) has become the most lethal human cancer because of the high rate of metastasis. Hence, clarifying the molecular mechanism underlying NSCLC metastasis is very important to improve the prognosis of patients with NSCLC. Long non-coding RNAs (LncRNAs) are a class of RNA molecules longer than 200 nucleotides, which can participate in diverse biological processes. About 18% of human LncRNAs were recently found to be associated with tumours. Many studies indicated that aberrant expression of LncRNAs played key roles in the progression and metastasis of NSCLC. According to the function in tumours, LncRNAs can be divided into two classes: oncogenic LncRNAs and tumour-suppressor LncRNAs. In this review, we summarized the main molecular mechanism of LncRNAs regulating NSCLC metastasis, including three aspects: (a) LncRNAs interact with miRNAs as ceRNAs; (b) LncRNAs bind with target proteins; and (c) LncRNAs participate in the transduction of different signal pathways. Then, LncRNAs can exert their function to regulate the metastasis of NSCLC through influencing the progression of epithelial-mesenchymal transition (EMT) and the properties of cancer stem cell (CSC). But, it is necessary to do some further research to demonstrate the LncRNAs particular regulatory mechanism of inhibiting the metastasis of NSCLC and explore new drugs targeting LncRNAs.
非小细胞肺癌（NSCLC）由于转移率高，已成为最致命的人类癌症。因此，阐明 NSCLC 转移的分子机制对于改善 NSCLC 患者的预后非常重要。长链非编码 RNA（LncRNA）是一类长度大于 200 个核苷酸的 RNA 分子，可参与多种生物学过程。最近发现，约 18%的人类 LncRNA 与肿瘤有关。许多研究表明，LncRNA 的异常表达在 NSCLC 的进展和转移中起着关键作用。根据在肿瘤中的功能，LncRNA 可分为两类：致癌 LncRNA 和肿瘤抑制 LncRNA。在这篇综述中，我们总结了 LncRNA 调节 NSCLC 转移的主要分子机制，包括三个方面：（a）LncRNA 作为 ceRNA 与 miRNA 相互作用；（b）LncRNA 与靶蛋白结合；（c）LncRNA 参与不同信号通路的转导。然后，LncRNA 可以通过影响上皮-间充质转化（EMT）的进展和癌症干细胞（CSC）的特性来发挥其功能，从而调节 NSCLC 的转移。但是，有必要进行进一步的研究来证明 LncRNA 抑制 NSCLC 转移的特定调节机制，并探索针对 LncRNA 的新药。
