College of Pharmaceutical Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
China Pharmaceutical University, Nanjing 210000, China.
Nano Lett. 2020 Mar 11;20(3):2137-2143. doi: 10.1021/acs.nanolett.0c00147. Epub 2020 Feb 17.
Photothermal therapy (PTT) is an effective approach to cancer therapy. However, the high temperature during the therapy increases the damage to surrounding normal tissues. Thermochromic material, which exhibits temperature-activated color change and optical absorption, is a promising photothermal agent for precisely temperature-controlled PTT. Nevertheless, the construction of nanosized thermochromic particles with an appropriate transition temperature (44-47 °C) is still a great challenge. Here, thermochromic nanoparticles with the transition temperature at 45 °C based on a leuco dye-developer-solvent system are developed for thermostatic photothermal tumor therapy. Below the temperature, the nanoparticles take a dark green color to absorb light and convert it into heat efficiently. Once the temperature reaches the transition point, the colored nanoparticles switch to a colorless state, maintaining the temperature at the predefined level and allowing deeper light penetration. The autoregulated nanoparticles exhibit a prominent therapeutic effect for the tumor without destroying normal tissues.
光热疗法（PTT）是一种有效的癌症治疗方法。然而，治疗过程中的高温会增加对周围正常组织的损伤。温致变色材料在温度作用下发生颜色变化和光吸收，是一种有前途的光热试剂，可实现精确的温度控制 PTT。然而，构建具有适当转变温度（44-47°C）的纳米级温致变色颗粒仍然是一个巨大的挑战。在这里，基于隐色染料-显色剂-溶剂体系开发了具有 45°C 转变温度的温致变色纳米颗粒，用于恒温光热肿瘤治疗。在温度以下，纳米颗粒呈深绿色，可有效吸收光并将其转化为热能。一旦温度达到转变点，有色纳米颗粒就会转变为无色状态，将温度保持在预设水平，并允许更深的光穿透。自动调节纳米颗粒对肿瘤具有显著的治疗效果，而不会破坏正常组织。
