College of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, 471023, P. R. China.
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, P. R. China.
Adv Healthc Mater. 2017 Jul;6(14). doi: 10.1002/adhm.201700005. Epub 2017 May 2.
The study reports a biocompatible smart drug delivery system based on a doxorubicin (DOX) blending phase-change material of 1-pentadecanol loaded hollow magnetic Prussian blue nanoparticles, resulting in HMNP-PB@Pent@DOX. The system possesses concentration-dependent high thermogenesis (>50 °C) when applying a near-infrared (NIR) laser irradiation only for 5 min. Furthermore, the system realizes near "zero release" of drug and is efficiently triggered by NIR for drug delivery in an "on" and "off" manner, thus inducing cell apoptosis in vitro and in vivo. Moreover, the system clearly indicates tumor site with trimodal imaging of magnetic resonance imaging, photoacoustic tomography imaging, and infrared thermal imaging. Furthermore, the system achieves efficient chemo-photothermal combined tumor therapy in vivo with 808 nm laser irradiation for 5 min at 1.2 W cm , revealing the good tumor inhibition effect comparing with those of chemotherapy or photothermal therapy alone. The system is also confirmed to be biocompatible in regard to the mortality rate.
该研究报道了一种基于阿霉素（DOX）混合相变材料 1-十五醇负载中空磁性普鲁士蓝纳米粒子的生物相容性智能药物传递系统，得到 HMNP-PB@Pent@DOX。该系统在近红外（NIR）激光照射仅 5 分钟的情况下，表现出浓度依赖性的高热生成（>50°C）。此外，该系统实现了药物的近“零释放”，并能通过 NIR 高效触发药物输送，实现“开”和“关”两种方式，从而诱导体外和体内细胞凋亡。此外，该系统通过磁共振成像、光声断层扫描成像和红外热成像的三模态成像清晰地显示肿瘤部位。此外，该系统在 808nm 激光照射下，以 1.2W/cm 的功率照射 5 分钟，实现了高效的化学-光热联合肿瘤治疗，与单独化疗或光热治疗相比，具有良好的肿瘤抑制效果。该系统的死亡率也证实了其生物相容性。
