静脉注射免疫球蛋白治疗轻度认知障碍后大脑和视网膜中淀粉样蛋白的减少。
Reduction of Amyloid in the Brain and Retina After Treatment With IVIG for Mild Cognitive Impairment.
机构信息
Sutter Neuroscience Institute, Sacramento, CA, USA.
Sutter Institute for Medical Research (SIMR), Sacramento, CA, USA.
出版信息
Am J Alzheimers Dis Other Demen. 2020 Jan-Dec;35:1533317519899800. doi: 10.1177/1533317519899800.
OBJECTIVE
To assess whether intravenous immunoglobulin (IVIG) in subjects with mild cognitive impairment (MCI) results in a reduction in amyloid in the central nervous system (CNS).
METHODS
Five subjects with MCI underwent baseline Florbetapir positron emission tomography and retinal autofluorescent imaging. All were administered IVIG (Octagam 10%) at 0.4 g/kg every 14 days for a total of 5 infusions. After 3 months, standard uptake value ratio (SUVR) and amyloid retinal deposits were reassessed.
RESULTS
Three subjects had a reduction in amyloid SUVR and all 5 subjects had a reduction in amyloid retinal deposits in at least 1 eye.
CONCLUSIONS
A short course of IVIG over 2 months removes a measurable amount of amyloid from the CNS in persons with MCI.
目的
评估静脉注射免疫球蛋白（IVIG）是否会减少轻度认知障碍（MCI）患者中枢神经系统（CNS）中的淀粉样蛋白。
方法
5 名 MCI 患者接受基线 Florbetapir 正电子发射断层扫描和视网膜自发荧光成像。所有患者均接受 IVIG（Octagam 10%）0.4 g/kg，每 14 天一次，共 5 次输注。3 个月后，重新评估标准摄取值比（SUVR）和淀粉样蛋白视网膜沉积。
结果
3 名患者的淀粉样蛋白 SUVR 降低，所有 5 名患者至少有 1 只眼的淀粉样蛋白视网膜沉积减少。
结论
在 2 个月内给予短疗程 IVIG 可从 MCI 患者的 CNS 中清除可测量量的淀粉样蛋白。
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