Department of Pharmacy, Elazığ Fethi Sekin City Hospital, Elazığ, Turkey.
Department of Pharmacology, Faculty of Pharmacy, Inonu University, Malatya, Turkey.
Libyan J Med. 2020 Dec;15(1):1725991. doi: 10.1080/19932820.2020.1725991.
: The flowering parts of , known as 'Afat' in the southeastern Anatolia region of Turkey, are used as a tonic, an appetizer, and for the treatment of several mental disorders, including depression. The purpose of this study is to investigate the antidepressant effect of ethanol extract (GOEE) in a chronic mild stress-induced rat model, which was used to mimic a depressive state in humans, and to compare the effect with that of imipramine.: Male Sprague-Dawley rats were randomly divided into six groups: control, stress, treated with imipramine (positive control) and treated with GOEE at three different (200, 500, 1000 mg/kg) doses groups. The rats in all groups, except the control group, were exposed to chronic mild stress. At the end of the 3-week experimental period, biochemical and behavioral parameters were examined.: The results showed that treatment with GOEE or imipramine significantly improved rats' sucrose consumption which was diminished by chronic mild stress, restored serum levels of corticosterone and proinflammatory cytokines (interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)), prevented the increase of liver index of rats. Moreover, in the hippocampus tissue, decreased serotonin and noradrenaline levels were significantly increased by treatment with GOEE or imipramine, and antioxidant parameters (thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), and glutathione (GSH)) were significantly improved by treatment with GOEE though not with imipramine.: The data demonstrate that may exert its antidepressant activity by improving monoaminergic system disorders, and by favorably affecting the antioxidant, inflammatory and the endocrine mechanisms.
: 在土耳其东南部安纳托利亚地区，被称为“Afat”的部分开花植物被用作补品、开胃剂，用于治疗几种精神障碍，包括抑郁症。本研究旨在探讨慢性轻度应激诱导的大鼠模型中 的乙醇提取物 (GOEE) 的抗抑郁作用，该模型用于模拟人类的抑郁状态，并将其与丙咪嗪的作用进行比较。: 雄性 Sprague-Dawley 大鼠随机分为六组：对照组、应激组、用丙咪嗪（阳性对照）治疗组和用 GOEE 以三种不同剂量（200、500、1000 mg/kg）治疗组。除对照组外，所有组的大鼠均暴露于慢性轻度应激下。在为期 3 周的实验期结束时，检查了生化和行为参数。: 结果表明，GOEE 或丙咪嗪治疗显著改善了慢性轻度应激导致的蔗糖消耗减少的大鼠，恢复了血清皮质酮和促炎细胞因子（白细胞介素-6 (IL-6)、肿瘤坏死因子-α (TNF-α)）水平，并防止了大鼠肝指数的增加。此外，在海马组织中，GOEE 或丙咪嗪治疗可显著增加降低的 5-羟色胺和去甲肾上腺素水平，抗氧化参数（硫代巴比妥酸反应物质 (TBARS)、超氧化物歧化酶 (SOD) 和谷胱甘肽 (GSH)）也显著改善，但丙咪嗪治疗没有改善。: 数据表明， 可能通过改善单胺能系统紊乱，并通过有利地影响抗氧化、炎症和内分泌机制来发挥其抗抑郁作用。
