Division of Gastroenterology & Hepatology, Department of Internal Medicine, East Carolina University, Greenville, NC 27834, United States.
Department of Internal and Pediatric Medicine, East Carolina University, Greenville, NC 27834, United States.
Curr Clin Pharmacol. 2020;15(3):207-215. doi: 10.2174/1574884715666200212125035.
Constipation is a highly prevalent functional gastrointestinal disorder that may significantly affect the quality of life and health care costs. Treatment for constipation has been broadly reviewed by cognitive therapies, medications, and surgical interventions. Gut microbiota such as Bifidobacterium, Clostridium, Bacteroidetes, and Lactobacilli have been demonstrated in functional gastrointestinal disorders and prebiotics to play a role in augmenting their presence. Prebiotics are ingredients in foods that remain undigested, stimulating the bacteria. There are a variety of prebiotics; however, there exists only a handful of studies that describe their efficacy for chronic constipation. The purpose of this study is to review the available literature on the utility of different commercially available prebiotics in patients with functional and chronic idiopathic constipation. To fulfil the objectives of the study, published articles in the English language on databases such as Pubmed, Ovid Medline, and EMBASE were searched. The terms prebiotics, constipation, chronic constipation, functional constipation were used. We reviewed and included 21 randomized controlled trials exploring the role of prebiotics in constipated adults. Prebiotics are effective treatments for chronic idiopathic constipation and showed improvement in the stool consistency, number of bowel moments and bloating. Although which prebiotic formulary would promote improved symptoms of constipation is still not clear.
便秘是一种高发的功能性胃肠疾病，可能会严重影响生活质量和医疗保健费用。治疗便秘已广泛涉及认知疗法、药物和手术干预。双歧杆菌、梭菌、拟杆菌和乳杆菌等肠道微生物群已在功能性胃肠疾病中得到证实，并被认为对增强其存在发挥作用。益生菌是食物中的成分，未被消化，可刺激细菌。有多种益生菌，但只有少数研究描述了它们对慢性便秘的疗效。本研究旨在综述现有文献中不同市售益生菌在功能性和慢性特发性便秘患者中的应用。为了实现研究目标，在 Pubmed、Ovid Medline 和 EMBASE 等数据库中搜索了以益生菌、便秘、慢性便秘、功能性便秘为关键词的英文发表文章。我们回顾并纳入了 21 项随机对照试验，探讨了益生菌在成年便秘患者中的作用。益生菌是治疗慢性特发性便秘的有效方法，可改善粪便稠度、排便次数和腹胀。虽然哪种益生菌配方能更有效地改善便秘症状仍不清楚。
