RREB1 整合 TGF-β 和 RAS 信号以驱动 EMT。
RREB1 Integrates TGF-β and RAS Signals to Drive EMT.
机构信息
Department of Pharmacology, Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093, USA.
Department of Pharmacology, Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093, USA.
出版信息
Dev Cell. 2020 Feb 10;52(3):259-260. doi: 10.1016/j.devcel.2020.01.020.
TGF-β is long known to require Ras activation to induce EMT. In a recent issue of Nature, Massagué and colleagues (Su et al., 2020) identify RAS-responsive element binding protein 1 (RREB1) as a critical integrator of TGF-β and Ras signals during both developmental and cancer EMT programs.
TGF-β 长期以来被认为需要 Ras 激活来诱导 EMT。在最近一期的《自然》杂志上，Massagué 及其同事（Su 等人，2020 年）确定 Ras 反应元件结合蛋白 1（RREB1）是 TGF-β 和 Ras 信号在发育和癌症 EMT 程序中的关键整合因子。
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