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石杉碱甲对老年大鼠麻醉后海马炎症反应及神经营养因子的影响

Effects of huperzine A on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia.

作者信息

Cai Yi, Huang Penghan, Xie Yizu

机构信息

Master, Department of Anesthesiology, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, China. Design of the study, statistics analysis, final approval.

Bachelor, Department of Anesthesiology, People's Hospital of Bishan District, Chongqing 402760, China. Acquisition of data, final approval.

出版信息

Acta Cir Bras. 2020 Feb 7;34(12):e201901205. doi: 10.1590/s0102-865020190120000005. eCollection 2020.

DOI:10.1590/s0102-865020190120000005
PMID:32049185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7006372/
Abstract

PURPOSE

To investigate the effects of huperzine A (HupA) on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia.

METHODS

Thirty-six Sprague Dawley rats (20-22 months old) were randomly divided into control, isofluran, and isoflurane+HupA groups; 12 rats in each group. The isoflurane+HupA group was intraperitoneally injected with 0.2 mg/kg of HupA. After 30 min, isoflurane inhalation anesthesia was performed in the isoflurane and isoflurane+HupA groups. After 24 h from anesthesia, Morris water maze experiment and open-field test were performed. Hippocampal inflammatory and neurotrophic factors were determined.

RESULTS

Compared with isoflurane group, in isofluran+HupA group the escape latency of rats was significantly decreased (P < 0.05), the original platform quadrant residence time and traversing times were significantly increased (P < 0.05), the central area residence time was significantly increased (P < 0.05), the hippocampal tumor necrosis factor α, interleukin 6 and interleukin 1β levels were significantly decreased (P < 0.05), and the hippocampal nerve growth factor, brain derived neurotrophic factor and neurotrophin-3 levels were significantly increased (P < 0.05).

CONCLUSION

HupA may alleviate the cognitive impairment in rats after isoflurane anesthesia by decreasing inflammatory factors and increasing hippocampal neurotrophic factors in hippocampus tissue.

摘要

目的

探讨石杉碱甲（HupA）对老年大鼠麻醉后海马炎症反应及神经营养因子的影响。

方法

将36只20 - 22月龄的Sprague Dawley大鼠随机分为对照组、异氟烷组和异氟烷+HupA组，每组12只。异氟烷+HupA组腹腔注射0.2 mg/kg的HupA。30分钟后，异氟烷组和异氟烷+HupA组进行异氟烷吸入麻醉。麻醉24小时后，进行Morris水迷宫实验和旷场试验，并测定海马炎症和神经营养因子。

结果

与异氟烷组相比，异氟烷+HupA组大鼠的逃避潜伏期显著缩短（P < 0.05），原平台象限停留时间和穿越次数显著增加（P < 0.05），中央区域停留时间显著增加（P < 0.05），海马肿瘤坏死因子α、白细胞介素6和白细胞介素1β水平显著降低（P < 0.05），海马神经生长因子、脑源性神经营养因子和神经营养素-3水平显著升高（P < 0.05）。

结论

HupA可能通过降低炎症因子和增加海马组织中的神经营养因子来减轻异氟烷麻醉后大鼠的认知障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39a1/7006372/39855cabdbf7/1678-2674-acb-34-12-e201901205-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39a1/7006372/34f337d2de1b/1678-2674-acb-34-12-e201901205-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39a1/7006372/a7cfc7342ee4/1678-2674-acb-34-12-e201901205-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39a1/7006372/efd1c38f94ac/1678-2674-acb-34-12-e201901205-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39a1/7006372/8efde04caac2/1678-2674-acb-34-12-e201901205-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39a1/7006372/39855cabdbf7/1678-2674-acb-34-12-e201901205-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39a1/7006372/34f337d2de1b/1678-2674-acb-34-12-e201901205-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39a1/7006372/a7cfc7342ee4/1678-2674-acb-34-12-e201901205-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39a1/7006372/efd1c38f94ac/1678-2674-acb-34-12-e201901205-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39a1/7006372/8efde04caac2/1678-2674-acb-34-12-e201901205-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39a1/7006372/39855cabdbf7/1678-2674-acb-34-12-e201901205-gf05.jpg

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