Trauma Research Department, Swedish Medical Center, Englewood, CO, USA.
Trauma Research Department, St. Anthony Hospital, Lakewood, CO, USA.
Brain Inj. 2020 Mar 20;34(4):556-566. doi: 10.1080/02699052.2020.1725981. Epub 2020 Feb 12.
: Undergoing mild traumatic brain injury (mTBI) increases mortality risk, but it is unclear what drives this finding. This study explored associations with mortality in patients with mTBI.: This was a retrospective study of patients with mTBI and controls admitted to six level 1 trauma centers in 1/1/2009-12/31/2013. Mortality data were from the CDC National Death Index. Patients with mTBI were identified by ICD-9 code, Glasgow Coma Scale 13-15, Injury Severity Score (ISS) <16, and loss of consciousness ≤1 hour. Controls had hospital length of stay ≤24 hours, ISS<16, and no head injury.: This study included 964 patients with mTBI and 5,567 controls. mTBI was associated with a 47% increased 5-year mortality risk (HR = 1.47, 95% CL 1.08-2.01). Patients with mTBI were more likely to die of a neurodegenerative disease (17% vs 11%, = .119). Cardiovascular (HR = 1.80, 95% CL 1.17-2.77), neurological (HR = 3.33, 95% CL 2.07-5.38), and respiratory (HR = 1.70, 95% CL 1.01-2.86) comorbidities were associated with mortality in patients with mTBI.: Patients with mTBI are at increased mortality risk in the 5 years post-injury. Mortality in patients with mTBI was most influenced by preexisting conditions.
轻度创伤性脑损伤（mTBI）会增加死亡率，但不清楚是什么导致了这一发现。本研究探讨了 mTBI 患者死亡率的相关因素。
这是一项回顾性研究，纳入了 2009 年 1 月 1 日至 2013 年 12 月 31 日期间在 6 家 1 级创伤中心就诊的 mTBI 患者和对照者。死亡率数据来自疾病预防控制中心国家死亡指数。mTBI 患者的识别标准为 ICD-9 编码、格拉斯哥昏迷量表 13-15 分、损伤严重程度评分（ISS）<16 分和意识丧失≤1 小时。对照者的住院时间≤24 小时、ISS<16 分且无头部损伤。
本研究纳入了 964 例 mTBI 患者和 5567 例对照者。mTBI 患者 5 年死亡率风险增加 47%（HR=1.47，95%CI：1.08-2.01）。mTBI 患者更有可能死于神经退行性疾病（17%比 11%， =.119）。心血管疾病（HR=1.80，95%CI：1.17-2.77）、神经系统疾病（HR=3.33，95%CI：2.07-5.38）和呼吸系统疾病（HR=1.70，95%CI：1.01-2.86）与 mTBI 患者的死亡率相关。
mTBI 患者在受伤后 5 年内死亡风险增加。mTBI 患者的死亡率主要受既往疾病的影响。
