免疫激活标志物：预测甲状腺乳头状癌患者预警指标的新型生物标志物。
Markers of immune activation: novel biomarkers to predict the early-warning indicator of patients with papillary thyroid carcinoma.
机构信息
Department of pathology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, People's Republic of China.
Department of Clinical Laboratory Center, Shaoxing People's Hospital, Shaoxing, Zhejiang, People's Republic of China.
出版信息
Diagn Pathol. 2020 Feb 12;15(1):16. doi: 10.1186/s13000-020-00931-1.
BACKGROUND
Papillary thyroid carcinoma (PTC) is an indolent tumor that is exploding with increasing thyroid nodules (TN). Environmental carcinogens, lifestyle changes increased the incidence of thyroid carcinoma. With the development of B-ultrasound imaging, more and more thyroid cancer has been found. There has been a debate about whether thyroid cancer is overtreated.
METHODS
The expression of T cell subsets and plasma cytokines in 191 patients, including 79 patients with PTC (PTC group), 58 patients with thyroid nodules (TN group) and 54 healthy individuals (HP group) were analyzed by flow cytometry.
RESULTS
High levels of natural killer cells (NK) were detected in PTC and TN groups than in HP group. High activities of CD8HLA-DR and CD8CD38 showed a gradual upward trend from HP group to PTC group. The rise in the levels of TNF-α in PTC patients' was evident when compared with HP group. CD8CD38 showed a significant correlation with lymph node metastasis. CD8CD38 co-expression was higher in Nx stage than N stage, while the proportion of IL-10 was dramatically decreased in the Nx stage.
CONCLUSIONS
These results indicated that CD8CD38 might act as a biomarker of PTC lymph node metastasis. The combination of CD8HLA-DR, CD8CD38 and TNF-α can be used as useful biomarkers for the early-warning indicator of PTC.
背景
甲状腺乳头状癌（PTC）是一种惰性肿瘤，随着甲状腺结节（TN）的不断增加而迅速增多。环境致癌物、生活方式的改变使甲状腺癌的发病率增加。随着 B 超成像技术的发展，越来越多的甲状腺癌被发现。关于甲状腺癌是否过度治疗存在争议。
方法
通过流式细胞术分析了 191 例患者（包括 79 例 PTC 患者（PTC 组）、58 例甲状腺结节患者（TN 组）和 54 例健康个体（HP 组））T 细胞亚群和血浆细胞因子的表达。
结果
PTC 和 TN 组患者的自然杀伤细胞（NK）水平高于 HP 组。CD8HLA-DR 和 CD8CD38 的活性从 HP 组到 PTC 组呈逐渐升高趋势。与 HP 组相比，PTC 患者的 TNF-α水平升高。CD8CD38 与淋巴结转移有显著相关性。Nx 期的 CD8CD38 共表达率高于 N 期，而 Nx 期的 IL-10 比例显著降低。
结论
这些结果表明 CD8CD38 可能作为 PTC 淋巴结转移的生物标志物。CD8HLA-DR、CD8CD38 和 TNF-α 的联合可以作为 PTC 早期预警指标的有用生物标志物。
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