极低浓度气态二氧化氯对玻璃培养皿潮湿环境表面大肠杆菌、铜绿假单胞菌和鲍曼不动杆菌的作用
Effect of extremely low-concentration gaseous chlorine dioxide against surface Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii in wet conditions on glass dishes.
作者信息
Morino Hirofumi, Futatsukame Masafumi, Miura Takanori, Shibata Takashi
机构信息
Taiko Pharmaceutical Co., Ltd., Uchihonmachi 3-34-14, Suita, Osaka, 564-0032, Japan.
Kyoto Plant/R&D Center, 1-2-1 Hikaridai, Seikacho, Soraku-gun, Kyoto, 619-0237, Japan.
出版信息
BMC Res Notes. 2020 Feb 12;13(1):69. doi: 10.1186/s13104-020-4925-5.
OBJECTIVE
Healthcare-associated infections due to Gram-negative bacteria (GNB) are a major cause of mortality and morbidity throughout the world. The purpose of the research described here was to evaluate the possibility of using an extremely low-concentration gaseous chlorine dioxide (ClO, 0.01 ppmv, 0.028 mg/m) as a technique to reduce the risk of environmental infection by GNB. In this study we set up an exposure chamber (1 m) and used three types of GNB, namely Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii.
RESULTS
The extremely low-concentration gaseous ClO inactivated E. coli (> 2 log reductions, within 2 h), P. aeruginosa (> 4 log reductions, within 2 h) and A. baumannii (> 2 log reductions, within 3 h) in wet conditions on glass dishes. Treatment of moist environments with extremely low-concentration gaseous ClO may help to reduce the risk of environmental infection by GNB without harmful effects.
目的
革兰氏阴性菌（GNB）引起的医疗保健相关感染是全球死亡和发病的主要原因。本文所述研究的目的是评估使用极低浓度的气态二氧化氯（ClO，0.01 ppmv，0.028毫克/立方米）作为降低GNB引起环境感染风险的技术的可能性。在本研究中，我们设置了一个暴露室（1米），并使用了三种类型的GNB，即大肠杆菌、铜绿假单胞菌和鲍曼不动杆菌。
结果
在玻璃培养皿的潮湿条件下，极低浓度的气态ClO使大肠杆菌（2小时内>2个对数级减少）、铜绿假单胞菌（2小时内>4个对数级减少）和鲍曼不动杆菌（3小时内>2个对数级减少）失活。用极低浓度的气态ClO处理潮湿环境可能有助于降低GNB引起环境感染的风险，且无有害影响。
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