[一名8岁患有胭脂虫过敏男孩的病例报告]

[THE CASE REPORT OF A 8 YEARS OLD BOY WITH COCHINEAL ALLERGY].

作者信息

Hirase Satoshi, Takeo Naoko, Nakamura Masashi, Sato Nayu, Matsunaga Kayoko, Taniguchi Hiroaki, Ota Kunitaka

机构信息

Department of Pediatrics, Konan Medical Center.

Department of Dermatology, Faculty of Medicine, Oita University.

出版信息

Arerugi. 2020;69(1):48-52. doi: 10.15036/arerugi.69.48.

DOI:10.15036/arerugi.69.48

PMID:32051369

Abstract

BACKGROUND

Cochineal dyes are used as additives in various foods for the purpose of red coloration. On the other hand, although it has been reported as a causative agent of immediate allergy, most of them are adult women. We report a case of an 8-year-old boy who developed a cochineal allergy.Current disease history: He has been suffering from atopic dermatitis, bronchial asthma, and food allergies since childhood. At the age of seven, he experienced an unknown anaphylaxis reaction twice. When he was 8 years old, he ate a frankfurter containing hypoallergenic cochineal for the first time; cold sweat, intraoral discomfort, respiratory distress, and urticaria appeared throughout the body. His skin prick tests were positive, with a result of 2+to frankfurter and cochineal dyes (color value 0.1 and 0.01). In the immunoblot assay, binding of IgE antibody was observed with CC38K (the main component of cochineal) and a protein of approximately 80-200 kDa in the high molecular weight region.

DISCUSSION

We report a case of anaphylaxis with hypoallergenic cochineal onset in a school-age boy.

摘要

背景

胭脂虫红染料被用作各种食品的添加剂以实现红色着色。另一方面，尽管它已被报道为速发型过敏的致病因素，但大多数病例为成年女性。我们报告一例8岁男孩发生胭脂虫过敏的病例。

现病史

他自童年起就患有特应性皮炎、支气管哮喘和食物过敏。7岁时，他曾两次经历不明原因的过敏反应。8岁时，他首次食用了含有低敏胭脂虫红的法兰克福香肠；随后全身出现冷汗、口腔不适、呼吸窘迫和荨麻疹。他的皮肤点刺试验呈阳性，对法兰克福香肠和胭脂虫红染料（色值0.1和0.01）的结果为2+。在免疫印迹分析中，观察到IgE抗体与CC38K（胭脂虫的主要成分）以及高分子量区域中约80 - 200 kDa的一种蛋白质结合。