Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, Republic of Korea.
Department of Internal Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of Korea.
Sci Rep. 2020 Feb 12;10(1):2433. doi: 10.1038/s41598-020-59271-1.
We developed a diet and lifestyle score based on high sensitivity C-reactive protein (hsCRP), and investigated its association with odds of adenoma. We performed stepwise linear regression to develop the predicted hsCRP score among 23,330 participants in the Health Examinee Study and examined its association with colorectal adenoma among 1,711 participants in a cross-sectional study of colorectal adenoma. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) of colorectal adenoma using logistic regression models. Variances in hsCRP explained by body mass index were 61.1% in men and 64.5% in women in the prediction model. The increasing predicted hsCRP score was positively associated with colorectal adenoma (OR 1.71, 95% CI: 1.12-2.62; P = 0.011 in men; OR 2.86, 95% CI: 1.26-6.49; P = 0.019 in women). In subgroups, the associations differed by age and menopausal status among women, with stronger associations among women aged less than 50 years (OR 3.74, 95% CI: 1.77-7.90, p for interaction 0.014) or premenopausal women (OR 4.21, 95% CI: 2.12-8.36, p for interaction <0.001). The associations were more pronounced in the advanced or distal colon/rectum in men and in the advanced or proximal colon in women. The associations were attenuated after further adjustment for body mass index. In conclusion, we found that the predicted hsCRP score was positively associated with colorectal adenoma, suggesting that diet and lifestyle lowering inflammation may be a strategy to prevent colorectal neoplasia.
我们基于高敏 C 反应蛋白（hsCRP）制定了一种饮食和生活方式评分，并研究了其与腺瘤发生几率的关系。我们在健康体检研究中的 23330 名参与者中进行了逐步线性回归，以制定预测 hsCRP 评分，并在结直肠腺瘤的横断面研究中对 1711 名参与者进行了研究。我们使用逻辑回归模型估计了结直肠腺瘤的比值比（OR）和 95％置信区间（CI）。在预测模型中，hsCRP 对体重指数的解释方差在男性中为 61.1％，在女性中为 64.5％。hsCRP 评分的增加与结直肠腺瘤呈正相关（男性 OR 1.71，95％CI：1.12-2.62；P = 0.011；女性 OR 2.86，95％CI：1.26-6.49；P = 0.019）。在亚组分析中，年龄和女性绝经状态的差异在男性中存在差异，年龄小于 50 岁的女性（OR 3.74，95％CI：1.77-7.90，p 交互作用 0.014）或绝经前妇女（OR 4.21，95％CI：2.12-8.36，p 交互作用 <0.001）的相关性更强。在男性中，高级或远端结肠/直肠和女性中高级或近端结肠的相关性更为明显。在进一步调整体重指数后，相关性减弱。总之，我们发现预测的 hsCRP 评分与结直肠腺瘤呈正相关，这表明降低饮食和生活方式炎症可能是预防结直肠肿瘤的一种策略。
