Sardo Molmenti C L, Steck S E, Thomson C A, Hibler E A, Yang J, Shivappa N, Greenlee H, Wirth M D, Neugut A I, Jacobs E T, Hébert J R
a Department of Epidemiology , Mailman School of Public Health, Columbia University , New York , New York , USA.
b Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center , New York , New York , USA.
Nutr Cancer. 2017 Feb-Mar;69(2):238-247. doi: 10.1080/01635581.2017.1263752. Epub 2017 Jan 17.
No studies have evaluated the association between the dietary inflammatory index (DII) and colorectal adenoma recurrence. DII scores were calculated from a baseline food frequency questionnaire. Participants (n = 1727) were 40-80 years of age, enrolled in two Phase III clinical trials, who had ≥1 colorectal adenoma(s) removed within 6 months of study registration, and a follow-up colonoscopy during the trial. Multiple logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). No statistically significant associations were found between DII and odds of colorectal adenoma recurrence [ORs (95% CIs) = 0.93 (0.73, 1.18) and 0.95 (0.73, 1.22)] for subjects in the second and third DII tertiles, respectively, compared to those in the lowest tertile (P = 0.72). No associations were found for recurrent colorectal adenoma characteristics, including advanced recurrent adenomas, large size, villous histology, or anatomic location. While our study did not support an association between a proinflammatory diet and colorectal adenoma recurrence, future studies are warranted to elucidate the role of a proinflammatory diet on the early stages of colorectal carcinogenesis.
尚无研究评估饮食炎症指数（DII）与结直肠腺瘤复发之间的关联。DII评分由基线食物频率问卷计算得出。参与者（n = 1727）年龄在40至80岁之间，参加了两项III期临床试验，在研究登记后6个月内切除了≥1个结直肠腺瘤，并在试验期间进行了随访结肠镜检查。采用多因素logistic回归来估计比值比（OR）和95%置信区间（95%CI）。与最低三分位数的受试者相比，第二和第三DII三分位数的受试者中，DII与结直肠腺瘤复发几率之间未发现统计学显著关联[OR（95%CI）分别为0.93（0.73，1.18）和0.95（0.73，1.22）]（P = 0.72）。对于复发性结直肠腺瘤的特征，包括晚期复发性腺瘤、大尺寸、绒毛状组织学或解剖位置，未发现关联。虽然我们的研究不支持促炎饮食与结直肠腺瘤复发之间的关联，但未来有必要进行研究以阐明促炎饮食在结直肠癌发生早期阶段的作用。
