Upfold J B, Smith M S
School of Anatomy, University of NSW, Kensington, Australia.
Med Hypotheses. 1988 Sep;27(1):89-92. doi: 10.1016/0306-9877(88)90092-8.
Maternal hyperthermia of even short duration induces dramatic teratogenic (monster producing) effects in all experimental animals studied. In humans, several studies have reported cases analogous to some laboratory results in animal experiments, e.g., mental retardation, brain and nerve abnormalities and facial deformity. Recent computer-aided 3D reconstructions of pyramidal cells from guinea-pig brains subjected embryonically to a 1 hr stress at 44 degrees C environmental temperature, show that structural changes are induced in dendritic arbors. The alterations are greatest for dendritic segments closest to the cell body and are consistent with several reports linking topological and metrical anomalies with disturbances of brain function. We suggest that many cases of "idiopathic" subnormality are due to maternal hyperthermia during early pregnancy.
即使是短时间的母体体温过高，也会在所有研究的实验动物中诱发显著的致畸（产生畸形）效应。在人类中，多项研究报告了与动物实验中的一些实验室结果类似的病例，例如智力迟钝、大脑和神经异常以及面部畸形。最近，对在胚胎期于44摄氏度环境温度下经受1小时应激的豚鼠大脑锥体细胞进行的计算机辅助三维重建显示，树突状分支会发生结构变化。对于最靠近细胞体的树突段，变化最为显著，这与一些将拓扑和度量异常与脑功能障碍联系起来的报告一致。我们认为，许多“特发性”发育迟缓病例是由于孕早期母体体温过高所致。
