Division of Rheumatology, ÖGK Outpatient Department of Graz, 8010, Graz, Austria.
Institute of Pharmaceutical Sciences, University of Graz, 8010, Graz, Austria.
Rheumatol Int. 2020 Apr;40(4):511-521. doi: 10.1007/s00296-020-04526-3. Epub 2020 Feb 12.
Treating patients with inflammatory joint diseases (rheumatoid arthritis, psoriatic arthritis) according to established treatment algorithms often requires the simultaneous use of three or more medications to relieve symptoms and prevent long-term joint damage as well as disability.
To assess and give an overview on drug-drug interactions in the pharmacotherapy of inflammatory joint diseases with regards to their clinical relevance.
All possible drug combinations were evaluated using three commercially available drug interaction programs. In those cases where only limited/no data were found, a comprehensive hand search of Pubmed was carried out. Finally, the drug-drug interactions of all possible combinations were classified according to evidence-based medicine and a specifically generated relevance-based system.
All three interaction software programs showed consistent results. All detected interactions were combined in clearly structured tables.
A concise overview on drug-drug interactions is given. Especially in more sophisticated cases extensive knowledge of drug interactions supports optimisation of therapy and results in improved patient safety.
根据既定的治疗方案治疗炎性关节疾病（类风湿关节炎、银屑病关节炎）患者，通常需要同时使用三种或更多种药物来缓解症状并预防长期关节损伤和残疾。
评估并概述炎性关节疾病药物治疗中药物-药物相互作用的临床相关性。
使用三种市售药物相互作用程序评估所有可能的药物组合。在仅发现有限/无数据的情况下，对 Pubmed 进行了全面的手动搜索。最后，根据循证医学和专门生成的基于相关性的系统对所有可能组合的药物-药物相互作用进行分类。
所有三种交互软件程序均显示出一致的结果。所有检测到的相互作用都被组合在清晰结构化的表格中。
给出了药物-药物相互作用的简明概述。特别是在更复杂的情况下，广泛了解药物相互作用可支持治疗的优化，并提高患者的安全性。
