Han Hui, Fang Zhiqiang, Ye Xiangguang, Wu Hailei, Zuo Feng, Shi Quan, Mu Jinping, Xu Baoliang
Chinese Academy of Inspection and Quarantine, Beijing, China.
Anhui International Travel Health Care Centre, Hefei, China.
J Infect Dev Ctries. 2019 May 31;13(5):394-399. doi: 10.3855/jidc.10147.
Despite high population immunity, pertussis remains one of the leading causes of vaccine-preventable deaths worldwide. The aim of this study was to determine the seroprevalence of IgG antibodies to pertussis toxin (PT) and diphtheria among the adult male population leaving or entering China.
Blood samples were obtained from 240 Chinese and 207 African healthy adults that were leaving and entering China, respectively. Serum IgG antibodies against PT (anti-PT IgG) and diphtheria were determined.
The mean concentration of anti-PT IgG antibodies was 13.82 IU/mL and 18.11 IU/mL for the leaving and entering populations, respectively. None of the studied Chinese leaving China were seropositive for pertussis. Of the 240 subjects leaving China, 209 (87.1%) had anti-diphtheria antibody concentrations of ≥ 0.1 IU/mL and 31 (12.9%) had antibody concentrations between 0.01 and 0.099 IU/mL. Eleven (5.31%) of the studied Africans entering China had anti-PT IgG antibodies higher than 30 IU/mL and thus were considered seropositive for pertussis. Of the 207 Africans entering China, antibody concentrations of ≥ 0.1 IU/mL were found in 164 subjects (79.2%) while 43 (20.8%) had antibody concentrations between 0.01 and 0.099 IU/mL.
Almost all Chinese adult men leaving China and most African men entering China have very low serum antibody levels of pertussis. Furthermore, the antibody level of diphtheria among these two populations was low among adults. A larger population study is needed to determine whether booster vaccinations against pertussis and diphtheria should be considered for adults in China and also for Africans entering China.
尽管人群免疫力较高，但百日咳仍是全球疫苗可预防死亡的主要原因之一。本研究的目的是确定出入境中国的成年男性人群中抗百日咳毒素（PT）IgG抗体和白喉抗体的血清阳性率。
分别从240名即将离境和207名即将入境中国的中国和非洲健康成年人中采集血样。检测血清中抗PT IgG抗体和白喉抗体。
离境人群和入境人群抗PT IgG抗体的平均浓度分别为13.82 IU/mL和18.11 IU/mL。所有离境中国人群中百日咳血清学均为阴性。在240名离境中国受试者中，209名（87.1%）抗白喉抗体浓度≥0.1 IU/mL，31名（12.9%）抗体浓度在0.01至0.099 IU/mL之间。11名（5.31%）入境中国的非洲受试者抗PT IgG抗体高于30 IU/mL，因此被认为百日咳血清学阳性。在207名入境中国的非洲人中，164名（79.2%）抗体浓度≥0.1 IU/mL，43名（20.8%）抗体浓度在0.01至0.099 IU/mL之间。
几乎所有离境中国成年男性和大多数入境中国的非洲男性百日咳血清抗体水平都非常低。此外，这两个人群中成年人的白喉抗体水平也较低。需要进行更大规模的人群研究，以确定是否应考虑对中国成年人以及入境中国的非洲人进行百日咳和白喉加强免疫接种。
