计算机断层扫描检测和定量肾纤维化。
Detection and quantification of renal fibrosis by computerized tomography.
机构信息
Department of Medicine, University of Maryland Baltimore School of Medicine, Baltimore, Maryland, United States of America.
Baltimore Veterans Affairs Medical Center, Baltimore, Maryland, United States of America.
出版信息
PLoS One. 2020 Feb 13;15(2):e0228626. doi: 10.1371/journal.pone.0228626. eCollection 2020.
OBJECTIVES
Reliable biomarkers for renal fibrosis are needed for clinical care and for research. Existing non-invasive biomarkers are imprecise, which has limited their utility.
METHODS
We developed a method to quantify fibrosis by subject size-adjusted CT Hounsfield units. This was accomplished using CT measurements of renal cortex in previously irradiated non-human primates.
RESULTS
Renal cortex mean CT Hounsfield units that were adjusted for body size had a very good direct correlation with renal parenchymal fibrosis, with an area under the curve of 0.93.
CONCLUSIONS
This metric is a promising and simple non-invasive biomarker for renal fibrosis.
目的
临床护理和研究都需要可靠的肾纤维化生物标志物。现有的非侵入性生物标志物不够精确，限制了它们的应用。
方法
我们开发了一种通过对 CT 亨氏单位进行受试者体型校正来定量纤维化的方法。该方法使用先前接受过辐射的非人类灵长类动物的肾皮质 CT 测量来实现。
结果
经体型校正的肾皮质平均 CT 亨氏单位与肾实质纤维化有很好的直接相关性，曲线下面积为 0.93。
结论
该指标是一种有前途且简单的肾纤维化非侵入性生物标志物。
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