内界膜异位的视网膜前膜中 M2 型巨噬细胞标志物升高。
Elevated M2 Macrophage Markers in Epiretinal Membranes With Ectopic Inner Foveal Layers.
机构信息
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出版信息
Invest Ophthalmol Vis Sci. 2020 Feb 7;61(2):19. doi: 10.1167/iovs.61.2.19.
PURPOSE
To analyze the differences in the vitreous cytokine profiles in epiretinal membrane eyes with and without an ectopic inner foveal layer (EIFL).
METHODS
Sixty eyes with epiretinal membrane (32 eyes without EIFL and 28 eyes with EIFL) were included. The vitreous samples were collected during surgery for epiretinal membrane. The cytokine levels of the vitreous were measured using a multiplex bead analysis.
RESULTS
The mean logMAR visual acuity was worse (0.42 vs. 0.37; P = 0.331) and the central foveal thickness was higher in the EIFL group (496.9 µm vs. 434.2 µm; P = 0.007) than they were in the group without EIFL. The mean EIFL thickness was 164.1 ± 67.7 µm in the EIFL group. On multiplex analysis of the vitreous cytokines, the levels of CD163 (21529 pg/dL vs. 10877 pg/dL; P = 0.002) and macrophage colony-stimulating factor (206 pg/dL vs. 159 pg/dL, P = 0.004) were significantly higher in the EIFL group than they were in the group without EIFL.
CONCLUSIONS
Eyes with EIFL had increased vitreous levels of M2 macrophage markers. The activation of glial cell proliferation by M2 macrophages may contribute to EIFL formation.
目的
分析伴有和不伴有异位内黄斑层（EIFL）的视网膜前膜眼中玻璃体细胞因子谱的差异。
方法
纳入 60 只患有视网膜前膜的眼（32 只眼无 EIFL，28 只眼有 EIFL）。在进行视网膜前膜手术时收集玻璃体样本。使用多重珠分析测量玻璃体细胞因子水平。
结果
EIFL 组的平均对数视力更差（0.42 与 0.37；P = 0.331），中央黄斑厚度更高（496.9 µm 与 434.2 µm；P = 0.007）。EIFL 组的平均 EIFL 厚度为 164.1 ± 67.7 µm。在玻璃体细胞因子的多重分析中，EIFL 组的 CD163（21529 pg/dL 与 10877 pg/dL；P = 0.002）和巨噬细胞集落刺激因子（206 pg/dL 与 159 pg/dL，P = 0.004）水平明显高于无 EIFL 组。
结论
伴有 EIFL 的眼玻璃体中 M2 巨噬细胞标志物水平升高。M2 巨噬细胞激活胶质细胞增殖可能有助于 EIFL 的形成。
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