miRNAs 和 LncRNAs：在 TGF-β 信号通路调控的肺癌转移中的双重作用。
MiRNAs and LncRNAs: Dual Roles in TGF-β Signaling-Regulated Metastasis in Lung Cancer.
机构信息
Department of Pathophysiology, Jiangxi Province Key Laboratory of Tumor Pathogenesis and Molecular Pathology, Medical College, Nanchang University, 461 Bayi Road, Nanchang 330006, China.
出版信息
Int J Mol Sci. 2020 Feb 11;21(4):1193. doi: 10.3390/ijms21041193.
Lung cancer is one of the most malignant cancers around the world, with high morbidity and mortality. Metastasis is the leading cause of lung cancer deaths and treatment failure. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs), two groups of small non-coding RNAs (nc-RNAs), are confirmed to be lung cancer oncogenes or suppressors. Transforming growth factor-β (TGF-β) critically regulates lung cancer metastasis. In this review, we summarize the dual roles of miRNAs and lncRNAs in TGF-β signaling-regulated lung cancer epithelial-mesenchymal transition (EMT), invasion, migration, stemness, and metastasis. In addition, lncRNAs, competing endogenous RNAs (ceRNAs), and circular RNAs (circRNAs) can act as miRNA sponges to suppress miRNAs, thereby mediating TGF-β signaling-regulated lung cancer invasion, migration, and metastasis. Through this review, we hope to cast light on the regulatory mechanisms of miRNAs and lncRNAs in TGF-β signaling-regulated lung cancer metastasis and provide new insights for lung cancer treatment.
肺癌是全球最恶性的癌症之一，具有高发病率和死亡率。转移是导致肺癌死亡和治疗失败的主要原因。微小 RNA（miRNA）和长链非编码 RNA（lncRNA）是两组小的非编码 RNA（ncRNA），已被证实是肺癌癌基因或抑癌基因。转化生长因子-β（TGF-β）对肺癌转移具有关键调控作用。在本综述中，我们总结了 miRNA 和 lncRNA 在 TGF-β 信号调控的肺癌上皮-间充质转化（EMT）、侵袭、迁移、干性和转移中的双重作用。此外，lncRNA、竞争内源性 RNA（ceRNA）和环状 RNA（circRNA）可以作为 miRNA 海绵来抑制 miRNA，从而介导 TGF-β 信号调控的肺癌侵袭、迁移和转移。通过本综述，我们希望揭示 miRNA 和 lncRNA 在 TGF-β 信号调控的肺癌转移中的调控机制，并为肺癌治疗提供新的思路。
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