Halvorsen Nils Erik, Kvernenes Ole Heine
Center for Nuclear medicine/PET, Department of Radiology, Haukeland University Hospital, Jonas Lies vei 65, N-5021 Bergen, Norway.
Pharmaceuticals (Basel). 2020 Feb 11;13(2):27. doi: 10.3390/ph13020027.
A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various F-radiopharmaceuticals is described. The test can be performed in less than five minutes. Iodoplatinate-saturated TLC plates are initially spotted with the F-radiopharmaceutical to be tested and TBA, then with deionized water or hydrogen peroxide (HO) solution, depending on if an antioxidant stabilizer is part of the pharmaceutical matrix. A distinct brown spot is visible at TBA concentrations of 50 µg/mL and up.
描述了一种用于测定各种F放射性药物中残留四丁基铵（TBA）的简单色斑试验。该试验可在不到五分钟内完成。首先在碘铂酸盐饱和的薄层色谱板上点上待测试的F放射性药物和TBA，然后根据药物基质中是否含有抗氧化稳定剂，再点上 deionized水或过氧化氢（HO）溶液。当TBA浓度达到50 µg/mL及以上时，会出现明显的棕色斑点。
