一种用于检测[18F]FDG制剂中Kryptofix 2.2.2的色斑试验。

A color spot test for the detection of Kryptofix 2.2.2 in [18F]FDG preparations.

作者信息

Mock B H, Winkle W, Vavrek M T

机构信息

Department of Radiology, Indiana University Hospital, Indianapolis 46202-5253, USA.

出版信息

Nucl Med Biol. 1997 Feb;24(2):193-5. doi: 10.1016/s0969-8051(96)00212-0.

DOI:10.1016/s0969-8051(96)00212-0

PMID:9089712

Abstract

A color spot test is described that can confirm the absence of Kryptofix 2.2.2 in 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) in less than 5 min. Pretreated strips of plastic-backed silica gel 60 thin-layer chromatographic medium, saturated with iodoplatinate reagent, are over-spotted with separate droplets of final product [18F]FDG and Kryptofix standard solutions. A blue-black circular spot is clearly visible at Kryptofix concentrations as low as 2 micrograms/mL.

摘要

本文描述了一种色斑试验，该试验可在不到5分钟的时间内确认2-[18F]氟-2-脱氧-D-葡萄糖（[18F]FDG）中不存在Kryptofix 2.2.2。预先用氯铂酸盐试剂饱和处理过的塑料背衬硅胶60薄层色谱介质条，分别用最终产物[18F]FDG和Kryptofix标准溶液的液滴进行点样。在低至2微克/毫升的Kryptofix浓度下，可清晰看到蓝黑色圆形斑点。