Normandie Université, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000 Caen, France.
Pôle Hospitalo-Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Centre Hospitalier Guillaume Régnier, Université Rennes 1, 35700 Rennes, France.
Science. 2020 Feb 14;367(6479). doi: 10.1126/science.aay8477.
In the aftermath of trauma, little is known about why the unwanted and unbidden recollection of traumatic memories persists in some individuals but not others. We implemented neutral and inoffensive intrusive memories in the laboratory in a group of 102 individuals exposed to the 2015 Paris terrorist attacks and 73 nonexposed individuals, who were not in Paris during the attacks. While reexperiencing these intrusive memories, nonexposed individuals and exposed individuals without posttraumatic stress disorder (PTSD) could adaptively suppress memory activity, but exposed individuals with PTSD could not. These findings suggest that the capacity to suppress memory is central to positive posttraumatic adaptation. A generalized disruption of the memory control system could explain the maladaptive and unsuccessful suppression attempts often seen in PTSD, and this disruption should be targeted by specific treatments.
在创伤后,人们对为什么有些人会持续地产生不必要和不受欢迎的创伤记忆,而有些人则不会,知之甚少。我们在实验室中对一组 102 名经历过 2015 年巴黎恐怖袭击的个体和 73 名未暴露于袭击的个体实施了中性和无害的侵入性记忆。在重新体验这些侵入性记忆时,未暴露于袭击的个体和没有创伤后应激障碍(PTSD)的暴露个体可以适应性地抑制记忆活动,但有 PTSD 的暴露个体则不能。这些发现表明,抑制记忆的能力是积极创伤后适应的核心。记忆控制系统的普遍破坏可以解释 PTSD 中经常出现的适应不良和不成功的抑制尝试,这种破坏应该是特定治疗的目标。