Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa, 920-8640, Japan.
Komatsu University, Komatsu, 923-0921, Japan.
Glycoconj J. 2021 Jun;38(3):303-310. doi: 10.1007/s10719-020-09956-6. Epub 2020 Oct 27.
The receptor for advanced glycation end-products (receptor for AGEs, RAGE) is a pattern recognition receptor. The interaction of RAGE with its ligands, such as AGEs, S100 proteins, high mobility group box-1 (HMGB1), and lipopolysaccharides (LPS), is known to play a pivotal role in the propagation of immune responses and inflammatory reactions. The ligand-RAGE interaction elicits cellular responses, for example, in myeloid and lymphoid cells, through distinct pathways by activating NF-κB and Rac1/cdc42, which lead to cytokine production, cell migration, phagocytosis, maturation, and polarization. Recently, oxytocin, a peptide hormone and neuropeptide, was identified as a novel binding molecule for the RAGE; however, it cannot compete with the interaction of RAGE with other ligands or induce RAGE intracellular signaling. The RAGE transports oxytocin from the blood into the brain and regulates brain functions. In this review, we summarize the current understanding of glycation reaction, AGEs, and the RAGE-mediated biological responses as well as the physiological role of RAGE in immunity and social behaviors, particularly, maternal bonding.
晚期糖基化终产物受体（RAGE）是一种模式识别受体。RAGE 与其配体（如 AGEs、S100 蛋白、高迁移率族蛋白 B1（HMGB1）和脂多糖（LPS））的相互作用被认为在免疫反应和炎症反应的传播中起着关键作用。配体-RAGE 相互作用通过激活 NF-κB 和 Rac1/cdc42 来引发细胞反应，例如在髓样细胞和淋巴样细胞中，从而导致细胞因子产生、细胞迁移、吞噬作用、成熟和极化。最近，催产素，一种肽激素和神经肽，被鉴定为 RAGE 的新型结合分子；然而，它不能与 RAGE 与其他配体的相互作用竞争，也不能诱导 RAGE 细胞内信号转导。RAGE 将催产素从血液中转运到大脑中，并调节大脑功能。在这篇综述中，我们总结了糖基化反应、AGEs 以及 RAGE 介导的生物学反应的最新认识，以及 RAGE 在免疫和社会行为中的生理作用，特别是母婴联系。
