Yu Yang, Yin Yan-Hua, Min Li, Zhu Sheng-Tao, Li Peng, Zhang Shu-Tian
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing 100050, China.
Department of Pathology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, China.
Chronic Dis Transl Med. 2020 Jan 8;5(4):234-242. doi: 10.1016/j.cdtm.2019.12.002. eCollection 2019 Dec.
Translational medicine is a new medical model that has emerged over the past 20 years and is dedicated to bridging the gap between basic and clinical research. At the same time, the diagnosis and treatment of digestive diseases, especially gastrointestinal endoscopy, have been rapidly developed. The emergence of new techniques for gastrointestinal endoscopy has changed the therapeutic spectrum of some diseases and brought huge benefits to patients. Targeted therapy has positively affected the individualized and precise treatment of patients with advanced gastrointestinal cancer. The construction of a standardized biobank provides a strong guarantee for clinicians to conduct translational medical research. Translational medicine has brought good development opportunities, but it also faces challenges. The training of translational medicine researchers and the transformation of educational models require sufficient attention for further development.
转化医学是过去20年中出现的一种新的医学模式，致力于弥合基础研究与临床研究之间的差距。与此同时，消化系统疾病的诊断和治疗，尤其是胃肠内镜检查，得到了迅速发展。胃肠内镜新技术的出现改变了一些疾病的治疗范围，给患者带来了巨大益处。靶向治疗对晚期胃肠道癌患者的个体化精准治疗产生了积极影响。标准化生物样本库的建设为临床医生开展转化医学研究提供了有力保障。转化医学带来了良好的发展机遇，但也面临挑战。转化医学研究人员的培训和教育模式的转变需要得到充分重视以实现进一步发展。
