Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Perimeter Institute for Theoretical Physics, Waterloo, ON, N2L 2Y5, Canada.
Theory Biosci. 2020 Jun;139(2):135-144. doi: 10.1007/s12064-020-00308-4. Epub 2020 Feb 13.
Extending the previous 2-gender dioecious diploid gene-mating evolution model, we attempt to answer "whether the Hardy-Weinberg global stability and the exact analytic dynamical solutions can be found in the generalized N-gender N-polyploid gene-mating system with arbitrary number of alleles?" For a 2-gender gene-mating evolution model, a pair of male and female determines the trait of their offspring. Each of the pair contributes one inherited character, the allele, to combine into the genotype of their offspring. Hence, for an N-gender N-polypoid gene-mating model, each of N different genders contributes one allele to combine into the genotype of their offspring. We exactly solve the analytic solution of N-gender-mating $(n+1)$-alleles governing highly nonlinear coupled differential equations in the genotype frequency parameter space for any positive integer N and $n$. For an analogy, the 2-gender to N-gender gene-mating equation generalization is analogs to the 2-body collision to the N-body collision Boltzmann equations with continuous distribution functions of discretized variables instead of continuous variables. We find their globally stable solution as a continuous manifold and find no chaos. Our solution implies that the Laws of Nature, under our assumptions, provide no obstruction and no chaos to support an N-gender gene-mating stable system.
在之前的两性二倍体雌雄异体二基因交配进化模型的基础上,我们尝试回答“在广义的 N 性别 N 倍体基因交配系统中,是否可以找到 Hardy-Weinberg 全局稳定性和精确的解析动力学解,其中任意数量的等位基因?”对于两性基因交配进化模型,一对雌雄决定了它们后代的特征。每一对都贡献一个遗传特征,即等位基因,将其组合成后代的基因型。因此,对于 N 性别 N 倍体基因交配模型,N 个不同性别中的每一个都贡献一个等位基因,将其组合成后代的基因型。我们准确地解决了 N 性别交配(n+1)等位基因的解析解,该解在基因型频率参数空间中对任何正整数 N 和 n 都存在高度非线性耦合微分方程。类比而言,2 性别到 N 性别基因交配方程的推广类似于 2 体碰撞到 N 体碰撞 Boltzmann 方程,其中离散变量的连续分布函数代替了连续变量。我们发现它们的全局稳定解是一个连续的流形,没有混沌。我们的解决方案表明,在我们的假设下,自然界的规律没有为支持 N 性别基因交配稳定系统提供任何障碍或混沌。