College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an, Shaanxi, 710021, China.
Shaanxi Key Laboratory of Chemical Additives for Industry, Shaanxi University of Science and Technology, Xi'an, Shaanxi, 710021, China.
Chem Asian J. 2020 Apr 1;15(7):1175-1179. doi: 10.1002/asia.202000059. Epub 2020 Mar 10.
A practical silver-catalyzed decarboxylative allylation of α,α-difluoroarylacetic acids with allyl sulfones is described, which provides a variety of β,β-difluorinated alkenes in good yields. Notably, the reaction proceeds smoothly in water with good functional group tolerance. The practicality and synthetic value of this process was demonstrated by scaled-up experiment and elaboration of the products via reduction or Heck reaction. Primary mechanism investigations suggest that a radical process might be involved.
本文描述了一种实用的银催化α,α-二氟芳基乙酸与烯丙基砜的脱羧烯丙基化反应，该反应以良好的收率得到了多种β,β-二氟烯烃。值得注意的是，该反应在水中能顺利进行，且对官能团具有良好的耐受性。通过放大实验以及通过还原或 Heck 反应对产物进行的详细研究，证明了该过程的实用性和合成价值。初步的机理研究表明，该反应可能涉及自由基过程。
